T cell receptor usage in neurological disease: the case in multiple sclerosis

Roland Martin, Henry F. McFarland

Research output: Contribution to journalArticlepeer-review

Abstract

With increasing evidence for an immunological mechanism in the cause of multiple sclerosis, the role of the T cell receptor has become increasingly important. Evidence from animals with experimental allergic encephalomyelitis (EAE) indicates that encephalitogenic T cells may have a restricted usage and that understanding this may lead to specific therapeutic approaches. Although numerous studies have examined the T cell receptor usage in myelin basic protein-specific T cells in humans, the question of restricted usage remains unsettled. Recent evidence evolving from T cell receptor sequences derived from multiple sclerosis lesions is encouraging but the genetic diversity of humans continues to make these areas of research difficult.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalSeminars in the Neurosciences
Volume4
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • immune response
  • multiple sclerosis
  • T cell receptor

ASJC Scopus subject areas

  • Neuroscience(all)

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