T cell priming by tissue-derived dendritic cells: New insights from recent murine studies

Fenna C.M. Sillé; Annelies Visser; Marianne Boes

doi:10.1016/j.cellimm.2005.10.004

T cell priming by tissue-derived dendritic cells: New insights from recent murine studies

Fenna C.M. Sillé, Annelies Visser, Marianne Boes

Research output: Contribution to journal › Review article › peer-review

Abstract

Dendritic cells (DCs) act as sentinels in peripheral tissues, continuously scavenging for antigens in their immediate surroundings. Their involvement in T cell responses is generally thought to consist of a linear progression of events, starting with capture of antigen in peripheral tissues such as the skin followed by migration to draining lymphoid organs and MHC-restricted presentation of antigen-derived peptide to induce T cell priming. The role of tissue-derived DCs in the direct priming of immune responses has lately been challenged. It now appears that, at least in some instances, a non-migratory subtype of DCs in the secondary lymphoid tissue presents tissue-derived antigen to T cells. Here, we review recent developments in research on DC function in the priming of immune responses.

Original language	English (US)
Pages (from-to)	77-85
Number of pages	9
Journal	Cellular Immunology
Volume	237
Issue number	2
DOIs	https://doi.org/10.1016/j.cellimm.2005.10.004
State	Published - Oct 2005
Externally published	Yes

Keywords

DC migration
DC subsets
T cell priming

ASJC Scopus subject areas

Immunology

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10.1016/j.cellimm.2005.10.004

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title = "T cell priming by tissue-derived dendritic cells: New insights from recent murine studies",

abstract = "Dendritic cells (DCs) act as sentinels in peripheral tissues, continuously scavenging for antigens in their immediate surroundings. Their involvement in T cell responses is generally thought to consist of a linear progression of events, starting with capture of antigen in peripheral tissues such as the skin followed by migration to draining lymphoid organs and MHC-restricted presentation of antigen-derived peptide to induce T cell priming. The role of tissue-derived DCs in the direct priming of immune responses has lately been challenged. It now appears that, at least in some instances, a non-migratory subtype of DCs in the secondary lymphoid tissue presents tissue-derived antigen to T cells. Here, we review recent developments in research on DC function in the priming of immune responses.",

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T2 - New insights from recent murine studies

AU - Sillé, Fenna C.M.

AU - Visser, Annelies

AU - Boes, Marianne

PY - 2005/10

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N2 - Dendritic cells (DCs) act as sentinels in peripheral tissues, continuously scavenging for antigens in their immediate surroundings. Their involvement in T cell responses is generally thought to consist of a linear progression of events, starting with capture of antigen in peripheral tissues such as the skin followed by migration to draining lymphoid organs and MHC-restricted presentation of antigen-derived peptide to induce T cell priming. The role of tissue-derived DCs in the direct priming of immune responses has lately been challenged. It now appears that, at least in some instances, a non-migratory subtype of DCs in the secondary lymphoid tissue presents tissue-derived antigen to T cells. Here, we review recent developments in research on DC function in the priming of immune responses.

AB - Dendritic cells (DCs) act as sentinels in peripheral tissues, continuously scavenging for antigens in their immediate surroundings. Their involvement in T cell responses is generally thought to consist of a linear progression of events, starting with capture of antigen in peripheral tissues such as the skin followed by migration to draining lymphoid organs and MHC-restricted presentation of antigen-derived peptide to induce T cell priming. The role of tissue-derived DCs in the direct priming of immune responses has lately been challenged. It now appears that, at least in some instances, a non-migratory subtype of DCs in the secondary lymphoid tissue presents tissue-derived antigen to T cells. Here, we review recent developments in research on DC function in the priming of immune responses.

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KW - DC subsets

KW - T cell priming

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T cell priming by tissue-derived dendritic cells: New insights from recent murine studies

Abstract

Keywords

ASJC Scopus subject areas

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