Abstract
Dendritic cells (DCs) act as sentinels in peripheral tissues, continuously scavenging for antigens in their immediate surroundings. Their involvement in T cell responses is generally thought to consist of a linear progression of events, starting with capture of antigen in peripheral tissues such as the skin followed by migration to draining lymphoid organs and MHC-restricted presentation of antigen-derived peptide to induce T cell priming. The role of tissue-derived DCs in the direct priming of immune responses has lately been challenged. It now appears that, at least in some instances, a non-migratory subtype of DCs in the secondary lymphoid tissue presents tissue-derived antigen to T cells. Here, we review recent developments in research on DC function in the priming of immune responses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 77-85 |
| Number of pages | 9 |
| Journal | Cellular Immunology |
| Volume | 237 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 2005 |
| Externally published | Yes |
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Keywords
- DC migration
- DC subsets
- T cell priming
ASJC Scopus subject areas
- Immunology
Cite this
T cell priming by tissue-derived dendritic cells : New insights from recent murine studies. / Sille, Fenna; Visser, Annelies; Boes, Marianne.
In: Cellular Immunology, Vol. 237, No. 2, 10.2005, p. 77-85.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - T cell priming by tissue-derived dendritic cells
T2 - New insights from recent murine studies
AU - Sille, Fenna
AU - Visser, Annelies
AU - Boes, Marianne
PY - 2005/10
Y1 - 2005/10
N2 - Dendritic cells (DCs) act as sentinels in peripheral tissues, continuously scavenging for antigens in their immediate surroundings. Their involvement in T cell responses is generally thought to consist of a linear progression of events, starting with capture of antigen in peripheral tissues such as the skin followed by migration to draining lymphoid organs and MHC-restricted presentation of antigen-derived peptide to induce T cell priming. The role of tissue-derived DCs in the direct priming of immune responses has lately been challenged. It now appears that, at least in some instances, a non-migratory subtype of DCs in the secondary lymphoid tissue presents tissue-derived antigen to T cells. Here, we review recent developments in research on DC function in the priming of immune responses.
AB - Dendritic cells (DCs) act as sentinels in peripheral tissues, continuously scavenging for antigens in their immediate surroundings. Their involvement in T cell responses is generally thought to consist of a linear progression of events, starting with capture of antigen in peripheral tissues such as the skin followed by migration to draining lymphoid organs and MHC-restricted presentation of antigen-derived peptide to induce T cell priming. The role of tissue-derived DCs in the direct priming of immune responses has lately been challenged. It now appears that, at least in some instances, a non-migratory subtype of DCs in the secondary lymphoid tissue presents tissue-derived antigen to T cells. Here, we review recent developments in research on DC function in the priming of immune responses.
KW - DC migration
KW - DC subsets
KW - T cell priming
UR - http://www.scopus.com/inward/record.url?scp=30944458189&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=30944458189&partnerID=8YFLogxK
U2 - 10.1016/j.cellimm.2005.10.004
DO - 10.1016/j.cellimm.2005.10.004
M3 - Review article
C2 - 16360134
AN - SCOPUS:30944458189
VL - 237
SP - 77
EP - 85
JO - Cellular Immunology
JF - Cellular Immunology
SN - 0008-8749
IS - 2
ER -