T cell priming by tissue-derived dendritic cells: New insights from recent murine studies

Fenna C.M. Sillé, Annelies Visser, Marianne Boes

Research output: Contribution to journalReview articlepeer-review

Abstract

Dendritic cells (DCs) act as sentinels in peripheral tissues, continuously scavenging for antigens in their immediate surroundings. Their involvement in T cell responses is generally thought to consist of a linear progression of events, starting with capture of antigen in peripheral tissues such as the skin followed by migration to draining lymphoid organs and MHC-restricted presentation of antigen-derived peptide to induce T cell priming. The role of tissue-derived DCs in the direct priming of immune responses has lately been challenged. It now appears that, at least in some instances, a non-migratory subtype of DCs in the secondary lymphoid tissue presents tissue-derived antigen to T cells. Here, we review recent developments in research on DC function in the priming of immune responses.

Original languageEnglish (US)
Pages (from-to)77-85
Number of pages9
JournalCellular Immunology
Volume237
Issue number2
DOIs
StatePublished - Oct 2005
Externally publishedYes

Keywords

  • DC migration
  • DC subsets
  • T cell priming

ASJC Scopus subject areas

  • Immunology

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