T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens

Michael A. Brehm, Amelia K. Pinto, Keith A. Daniels, Jonathan P. Schneck, Raymond M. Welsh, Liisa K. Selin

Research output: Contribution to journalArticlepeer-review

Abstract

We show here that T cell cross-reactivity between heterologous viruses influences the immunodominance of virus-specific CD8+ T cells by two mechanisms. First, T cells specific for cross-reactive epitopes dominate acute responses to viral infections; second, within the memory pool, T cells specific for cross-reactive epitopes are maintained while those specific for non-cross-reactive epitopes are selectively lost. These findings suggest an immunological paradigm in which viral infections shape the available T cell repertoire, causing alterations in the hierarchies of both the primary and memory CD8+ T cell responses elicited by subsequent viral infections. Thus, immunodominance is a function of the host's previous exposure to unrelated pathogens, and this may have an impact on protective immunity and immunopathology.

Original languageEnglish (US)
Pages (from-to)627-634
Number of pages8
JournalNature Immunology
Volume3
Issue number7
DOIs
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens'. Together they form a unique fingerprint.

Cite this