T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens

Michael A. Brehm, Amelia K. Pinto, Keith A. Daniels, Jonathan P Schneck, Raymond M. Welsh, Liisa K. Selin

Research output: Contribution to journalArticle

Abstract

We show here that T cell cross-reactivity between heterologous viruses influences the immunodominance of virus-specific CD8+ T cells by two mechanisms. First, T cells specific for cross-reactive epitopes dominate acute responses to viral infections; second, within the memory pool, T cells specific for cross-reactive epitopes are maintained while those specific for non-cross-reactive epitopes are selectively lost. These findings suggest an immunological paradigm in which viral infections shape the available T cell repertoire, causing alterations in the hierarchies of both the primary and memory CD8+ T cell responses elicited by subsequent viral infections. Thus, immunodominance is a function of the host's previous exposure to unrelated pathogens, and this may have an impact on protective immunity and immunopathology.

Original languageEnglish (US)
Pages (from-to)627-634
Number of pages8
JournalNature Immunology
Volume3
Issue number7
DOIs
StatePublished - 2002

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Maintenance
T-Lymphocytes
Virus Diseases
Epitopes
Viruses
Immunity

ASJC Scopus subject areas

  • Immunology

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T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens. / Brehm, Michael A.; Pinto, Amelia K.; Daniels, Keith A.; Schneck, Jonathan P; Welsh, Raymond M.; Selin, Liisa K.

In: Nature Immunology, Vol. 3, No. 7, 2002, p. 627-634.

Research output: Contribution to journalArticle

Brehm, Michael A. ; Pinto, Amelia K. ; Daniels, Keith A. ; Schneck, Jonathan P ; Welsh, Raymond M. ; Selin, Liisa K. / T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens. In: Nature Immunology. 2002 ; Vol. 3, No. 7. pp. 627-634.
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