Abstract
We show here that T cell cross-reactivity between heterologous viruses influences the immunodominance of virus-specific CD8+ T cells by two mechanisms. First, T cells specific for cross-reactive epitopes dominate acute responses to viral infections; second, within the memory pool, T cells specific for cross-reactive epitopes are maintained while those specific for non-cross-reactive epitopes are selectively lost. These findings suggest an immunological paradigm in which viral infections shape the available T cell repertoire, causing alterations in the hierarchies of both the primary and memory CD8+ T cell responses elicited by subsequent viral infections. Thus, immunodominance is a function of the host's previous exposure to unrelated pathogens, and this may have an impact on protective immunity and immunopathology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 627-634 |
| Number of pages | 8 |
| Journal | Nature Immunology |
| Volume | 3 |
| Issue number | 7 |
| DOIs | |
| State | Published - 2002 |
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ASJC Scopus subject areas
- Immunology
Cite this
T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens. / Brehm, Michael A.; Pinto, Amelia K.; Daniels, Keith A.; Schneck, Jonathan P; Welsh, Raymond M.; Selin, Liisa K.
In: Nature Immunology, Vol. 3, No. 7, 2002, p. 627-634.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens
AU - Brehm, Michael A.
AU - Pinto, Amelia K.
AU - Daniels, Keith A.
AU - Schneck, Jonathan P
AU - Welsh, Raymond M.
AU - Selin, Liisa K.
PY - 2002
Y1 - 2002
N2 - We show here that T cell cross-reactivity between heterologous viruses influences the immunodominance of virus-specific CD8+ T cells by two mechanisms. First, T cells specific for cross-reactive epitopes dominate acute responses to viral infections; second, within the memory pool, T cells specific for cross-reactive epitopes are maintained while those specific for non-cross-reactive epitopes are selectively lost. These findings suggest an immunological paradigm in which viral infections shape the available T cell repertoire, causing alterations in the hierarchies of both the primary and memory CD8+ T cell responses elicited by subsequent viral infections. Thus, immunodominance is a function of the host's previous exposure to unrelated pathogens, and this may have an impact on protective immunity and immunopathology.
AB - We show here that T cell cross-reactivity between heterologous viruses influences the immunodominance of virus-specific CD8+ T cells by two mechanisms. First, T cells specific for cross-reactive epitopes dominate acute responses to viral infections; second, within the memory pool, T cells specific for cross-reactive epitopes are maintained while those specific for non-cross-reactive epitopes are selectively lost. These findings suggest an immunological paradigm in which viral infections shape the available T cell repertoire, causing alterations in the hierarchies of both the primary and memory CD8+ T cell responses elicited by subsequent viral infections. Thus, immunodominance is a function of the host's previous exposure to unrelated pathogens, and this may have an impact on protective immunity and immunopathology.
UR - http://www.scopus.com/inward/record.url?scp=0036301672&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036301672&partnerID=8YFLogxK
U2 - 10.1038/ni806
DO - 10.1038/ni806
M3 - Article
C2 - 12055626
AN - SCOPUS:0036301672
VL - 3
SP - 627
EP - 634
JO - Nature Immunology
JF - Nature Immunology
SN - 1529-2908
IS - 7
ER -