T-cell homeostasis in HIV-1 infection

Joseph B. Margolick, Albert D. Donnenberg

Research output: Contribution to journalArticle

Abstract

Failure of T-cell homeostasis is an important feature of HIV-1 infection. Substantial evidence indicates that T-cell homeostasis is independent of CD4+ and CD8+ subsets, and this may contribute to the decline of CD4+ T cells to low levels in this disease. Moreover, failure of T-cell homeostasis appears to precede the development of clinically-defined AIDS by approximately 1.5 to 2 years and is thus an important milestone in HIV-1 disease progression. We argue that T-cell turnover and depletion of memory cells in HIV-1 infection can be viewed as the reverse of the process by which immune reconstitution occurs after stem cell transplantation, and that changes in the functional level of T-cell memory may be critical to both processes. An understanding of the relationship between T-cell memory and regeneration of lost T cells may help preserve and/or reconstitute immune system homeostasis in HIV-1-infected individuals.

Original languageEnglish (US)
Pages (from-to)381-388
Number of pages8
JournalSeminars in immunology
Volume9
Issue number6
DOIs
StatePublished - Dec 1997

Keywords

  • Apoptosis
  • CD45
  • Memory T cells
  • Naive T cells
  • Pronaive T cells
  • T cell turnover

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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