T cell factors involved in the regulation of the IgE synthesis

K. Ishizaka, P. Jardieu, M. Akasaki, M. Iwata

Research output: Contribution to journalReview articlepeer-review

Abstract

The IgE-potentiating and IgE-suppressive factors share a common structural gene and therefore a common polypeptide chain, and their biologic activities are decided by a post-translational glycosylation process. Under physiological conditions, this process is controlled by two T cell factors, i.e., the glycosylation-enhancing factor (GEF) and glycosylation-inhibiting factor (GIF). GIF is a fragment of phosphorylated lipocortin and has immunosuppressive effects. Repeated injections of this lymphokine into antigen-primed mice switched their T cells from the formation of IgE-potentiating factor to the formation of IgE-suppressive factor and facilitated the generation of antigen-specific suppressor T cells, which form antigen-specific GIF upon antigenic stimulation. The antigen-specific GIF suppressed the antibody response in a carrier-specific manner and has properties similar to antigen-specific suppressor T cell factors.

Original languageEnglish (US)
Pages (from-to)383-388
Number of pages6
JournalInternational archives of allergy and applied immunology
Volume82
Issue number3-4
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Immunology and Allergy

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