Abstract
Innate memory-like CD8 thymocytes develop and acquire effector function during maturation in the absence of encounter with Ags. In this study, we demonstrate that enhanced function of transcription factors T cell factor (TCF)-1 and β-catenin regulate the frequency of promyelocytic leukemia zinc finger (PLZF)-expressing, IL-4-producing thymocytes that promote the generation of eomesodermin-expressing memory-like CD8 thymocytes in trans. In contrast, TCF1-deficient mice do not have PLZF-expressing thymocytes and eomesodermin-expressing memory-like CD8 thymocytes. Generation of TCF1 and β-catenin-dependent memorylike CD8 thymocytes is non-cell-intrinsic and requires the expression of IL-4 and IL-4R. CD8 memory-like thymocytes migrate to the peripheral lymphoid organs, and the memory-like CD8 T cells rapidly produce IFN-γ. Thus, TCF1 and β-catenin regulate the generation of PLZF-expressing thymocytes and thereby facilitate the generation of memory-like CD8 T cells in the thymus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3859-3868 |
| Number of pages | 10 |
| Journal | Journal of Immunology |
| Volume | 188 |
| Issue number | 8 |
| DOIs | |
| State | Published - Apr 15 2012 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
T cell factor-1 and β-catenin control the development of memory-like CD8 thymocytes. / Sharma, Archna; Chen, Qinghua; Nguyen, Trang; Yu, Qing; Sen, Jyoti Misra.
In: Journal of Immunology, Vol. 188, No. 8, 15.04.2012, p. 3859-3868.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - T cell factor-1 and β-catenin control the development of memory-like CD8 thymocytes
AU - Sharma, Archna
AU - Chen, Qinghua
AU - Nguyen, Trang
AU - Yu, Qing
AU - Sen, Jyoti Misra
PY - 2012/4/15
Y1 - 2012/4/15
N2 - Innate memory-like CD8 thymocytes develop and acquire effector function during maturation in the absence of encounter with Ags. In this study, we demonstrate that enhanced function of transcription factors T cell factor (TCF)-1 and β-catenin regulate the frequency of promyelocytic leukemia zinc finger (PLZF)-expressing, IL-4-producing thymocytes that promote the generation of eomesodermin-expressing memory-like CD8 thymocytes in trans. In contrast, TCF1-deficient mice do not have PLZF-expressing thymocytes and eomesodermin-expressing memory-like CD8 thymocytes. Generation of TCF1 and β-catenin-dependent memorylike CD8 thymocytes is non-cell-intrinsic and requires the expression of IL-4 and IL-4R. CD8 memory-like thymocytes migrate to the peripheral lymphoid organs, and the memory-like CD8 T cells rapidly produce IFN-γ. Thus, TCF1 and β-catenin regulate the generation of PLZF-expressing thymocytes and thereby facilitate the generation of memory-like CD8 T cells in the thymus.
AB - Innate memory-like CD8 thymocytes develop and acquire effector function during maturation in the absence of encounter with Ags. In this study, we demonstrate that enhanced function of transcription factors T cell factor (TCF)-1 and β-catenin regulate the frequency of promyelocytic leukemia zinc finger (PLZF)-expressing, IL-4-producing thymocytes that promote the generation of eomesodermin-expressing memory-like CD8 thymocytes in trans. In contrast, TCF1-deficient mice do not have PLZF-expressing thymocytes and eomesodermin-expressing memory-like CD8 thymocytes. Generation of TCF1 and β-catenin-dependent memorylike CD8 thymocytes is non-cell-intrinsic and requires the expression of IL-4 and IL-4R. CD8 memory-like thymocytes migrate to the peripheral lymphoid organs, and the memory-like CD8 T cells rapidly produce IFN-γ. Thus, TCF1 and β-catenin regulate the generation of PLZF-expressing thymocytes and thereby facilitate the generation of memory-like CD8 T cells in the thymus.
UR - http://www.scopus.com/inward/record.url?scp=84860335309&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860335309&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.1103729
DO - 10.4049/jimmunol.1103729
M3 - Article
C2 - 22492686
AN - SCOPUS:84860335309
VL - 188
SP - 3859
EP - 3868
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 8
ER -