T cell factor-1 and β-catenin control the development of memory-like CD8 thymocytes

Archna Sharma, Qinghua Chen, Trang Nguyen, Qing Yu, Jyoti Misra Sen

Research output: Contribution to journalArticle

Abstract

Innate memory-like CD8 thymocytes develop and acquire effector function during maturation in the absence of encounter with Ags. In this study, we demonstrate that enhanced function of transcription factors T cell factor (TCF)-1 and β-catenin regulate the frequency of promyelocytic leukemia zinc finger (PLZF)-expressing, IL-4-producing thymocytes that promote the generation of eomesodermin-expressing memory-like CD8 thymocytes in trans. In contrast, TCF1-deficient mice do not have PLZF-expressing thymocytes and eomesodermin-expressing memory-like CD8 thymocytes. Generation of TCF1 and β-catenin-dependent memorylike CD8 thymocytes is non-cell-intrinsic and requires the expression of IL-4 and IL-4R. CD8 memory-like thymocytes migrate to the peripheral lymphoid organs, and the memory-like CD8 T cells rapidly produce IFN-γ. Thus, TCF1 and β-catenin regulate the generation of PLZF-expressing thymocytes and thereby facilitate the generation of memory-like CD8 T cells in the thymus.

Original languageEnglish (US)
Pages (from-to)3859-3868
Number of pages10
JournalJournal of Immunology
Volume188
Issue number8
DOIs
StatePublished - Apr 15 2012
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

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