T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors

Ahmad R. Sedaghat, Darius A Rastegar, Karen A. OConnell, Jason B. Dinoso, Claus O. Wilke, Joel N Blankson

Research output: Contribution to journalArticle

Abstract

Elite controllers or suppressors are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain undetectable viral loads. In this study, we show that most elite suppressors do not experience significant changes in T cell counts over a 10-year period. Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation.

Original languageEnglish (US)
Pages (from-to)1763-1766
Number of pages4
JournalClinical Infectious Diseases
Volume49
Issue number11
DOIs
StatePublished - Dec 2009

Fingerprint

Highly Active Antiretroviral Therapy
Viral Load
HIV-1
Cell Count
T-Lymphocytes
Therapeutics

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors. / Sedaghat, Ahmad R.; Rastegar, Darius A; OConnell, Karen A.; Dinoso, Jason B.; Wilke, Claus O.; Blankson, Joel N.

In: Clinical Infectious Diseases, Vol. 49, No. 11, 12.2009, p. 1763-1766.

Research output: Contribution to journalArticle

Sedaghat, Ahmad R. ; Rastegar, Darius A ; OConnell, Karen A. ; Dinoso, Jason B. ; Wilke, Claus O. ; Blankson, Joel N. / T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors. In: Clinical Infectious Diseases. 2009 ; Vol. 49, No. 11. pp. 1763-1766.
@article{f749ad1a76cb49eab861cafb0a68cb4a,
title = "T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors",
abstract = "Elite controllers or suppressors are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain undetectable viral loads. In this study, we show that most elite suppressors do not experience significant changes in T cell counts over a 10-year period. Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation.",
author = "Sedaghat, {Ahmad R.} and Rastegar, {Darius A} and OConnell, {Karen A.} and Dinoso, {Jason B.} and Wilke, {Claus O.} and Blankson, {Joel N}",
year = "2009",
month = "12",
doi = "10.1086/648081",
language = "English (US)",
volume = "49",
pages = "1763--1766",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "11",

}

TY - JOUR

T1 - T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors

AU - Sedaghat, Ahmad R.

AU - Rastegar, Darius A

AU - OConnell, Karen A.

AU - Dinoso, Jason B.

AU - Wilke, Claus O.

AU - Blankson, Joel N

PY - 2009/12

Y1 - 2009/12

N2 - Elite controllers or suppressors are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain undetectable viral loads. In this study, we show that most elite suppressors do not experience significant changes in T cell counts over a 10-year period. Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation.

AB - Elite controllers or suppressors are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain undetectable viral loads. In this study, we show that most elite suppressors do not experience significant changes in T cell counts over a 10-year period. Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation.

UR - http://www.scopus.com/inward/record.url?scp=72849143512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=72849143512&partnerID=8YFLogxK

U2 - 10.1086/648081

DO - 10.1086/648081

M3 - Article

C2 - 19857162

AN - SCOPUS:72849143512

VL - 49

SP - 1763

EP - 1766

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 11

ER -