T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors

Ahmad R. Sedaghat; Darius A. Rastegar; Karen A. OConnell; Jason B. Dinoso; Claus O. Wilke; Joel N. Blankson

doi:10.1086/648081

T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors

Ahmad R. Sedaghat, Darius A. Rastegar, Karen A. OConnell, Jason B. Dinoso, Claus O. Wilke, Joel N. Blankson

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Elite controllers or suppressors are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain undetectable viral loads. In this study, we show that most elite suppressors do not experience significant changes in T cell counts over a 10-year period. Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation.

Original language	English (US)
Pages (from-to)	1763-1766
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	49
Issue number	11
DOIs	https://doi.org/10.1086/648081
State	Published - Dec 2009

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1086/648081

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abstract = "Elite controllers or suppressors are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain undetectable viral loads. In this study, we show that most elite suppressors do not experience significant changes in T cell counts over a 10-year period. Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation.",

author = "Sedaghat, {Ahmad R.} and Rastegar, {Darius A.} and OConnell, {Karen A.} and Dinoso, {Jason B.} and Wilke, {Claus O.} and Blankson, {Joel N.}",

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AU - Wilke, Claus O.

AU - Blankson, Joel N.

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AB - Elite controllers or suppressors are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain undetectable viral loads. In this study, we show that most elite suppressors do not experience significant changes in T cell counts over a 10-year period. Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation.

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T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors

Abstract

ASJC Scopus subject areas

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