Abstract
Elite controllers or suppressors are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain undetectable viral loads. In this study, we show that most elite suppressors do not experience significant changes in T cell counts over a 10-year period. Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1763-1766 |
| Number of pages | 4 |
| Journal | Clinical Infectious Diseases |
| Volume | 49 |
| Issue number | 11 |
| DOIs | |
| State | Published - Dec 2009 |
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ASJC Scopus subject areas
- Infectious Diseases
- Microbiology (medical)
Cite this
T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors. / Sedaghat, Ahmad R.; Rastegar, Darius A; OConnell, Karen A.; Dinoso, Jason B.; Wilke, Claus O.; Blankson, Joel N.
In: Clinical Infectious Diseases, Vol. 49, No. 11, 12.2009, p. 1763-1766.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors
AU - Sedaghat, Ahmad R.
AU - Rastegar, Darius A
AU - OConnell, Karen A.
AU - Dinoso, Jason B.
AU - Wilke, Claus O.
AU - Blankson, Joel N
PY - 2009/12
Y1 - 2009/12
N2 - Elite controllers or suppressors are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain undetectable viral loads. In this study, we show that most elite suppressors do not experience significant changes in T cell counts over a 10-year period. Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation.
AB - Elite controllers or suppressors are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain undetectable viral loads. In this study, we show that most elite suppressors do not experience significant changes in T cell counts over a 10-year period. Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation.
UR - http://www.scopus.com/inward/record.url?scp=72849143512&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=72849143512&partnerID=8YFLogxK
U2 - 10.1086/648081
DO - 10.1086/648081
M3 - Article
C2 - 19857162
AN - SCOPUS:72849143512
VL - 49
SP - 1763
EP - 1766
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 11
ER -