T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women

Robert C. Kaplan, Elizabeth Sinclair, Alan L. Landay, Nell Lurain, A. Richey Sharrett, Stephen J Gange, Xiaonan Xue, Peter Hunt, Roksana Karim, David M. Kern, Howard N. Hodis, Steven G. Deeks

Research output: Contribution to journalArticle

Abstract

Background. Individuals infected with human immunodeficiency virus (HIV) have increased risk of cardiovascular events. It is unknown whether T cell activation and senescence, 2 immunologic sequelae of HIV infection, are associated with vascular disease among HIV-infected adults. Methods. T cell phenotyping and carotid ultrasound were assessed among 115 HIV-infected women and 43 age- and race/ethnicity-matched HIV-uninfected controls participating in the Women's Interagency HIV Study. Multivariate analyses were used to assess the association of T cell activation (CD38+HLA-DR+) and senescence (CD28-CD57+) with subclinical carotid artery disease. Results. Compared with HIV-uninfected women, frequencies of CD4 +CD38+HLA-DR+, CD8+CD38 +HLA-DR +, and CD8+CD28-CD57 + T cells were higher among HIV-infected women, including those who achieved viral suppression while receiving antiretroviral treatment. Among HIV-infected women, adjusted for age, antiretroviral medications, and viral load, higher frequencies of activated CD4+ and CD8+ T cells and immunosenescent CD8+ T cells were associated with increased prevalence of carotid artery lesions (prevalence ratiolesions associated with activated CD4+ T cells, 1.6 per SD [95% confidence interval {CI}, 1.1-2.2]; P = .02; prevalence ratiolesions associated with activated CD8+ T cells, 2.0 per SD [95% CI, 1.2-3.3]; P <.01; prevalence ratiolesions associated with senescent CD8 + T cells, 1.9 per SD [95% CI, 1.1-3.1]; P = .01). Conclusions. HIV-associated T cell changes are associated with subclinical carotid artery abnormalities, which may be observed even among those patients achieving viral suppression with effective antiretroviral therapy.

Original languageEnglish (US)
Pages (from-to)452-463
Number of pages12
JournalJournal of Infectious Diseases
Volume203
Issue number4
DOIs
StatePublished - Feb 15 2011

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Carotid Artery Diseases
Cell Aging
HIV
T-Lymphocytes
HLA-DR Antigens
Confidence Intervals
Carotid Arteries
Virus Diseases
Viral Load
Vascular Diseases
Multivariate Analysis

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Kaplan, R. C., Sinclair, E., Landay, A. L., Lurain, N., Sharrett, A. R., Gange, S. J., ... Deeks, S. G. (2011). T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women. Journal of Infectious Diseases, 203(4), 452-463. https://doi.org/10.1093/infdis/jiq071

T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women. / Kaplan, Robert C.; Sinclair, Elizabeth; Landay, Alan L.; Lurain, Nell; Sharrett, A. Richey; Gange, Stephen J; Xue, Xiaonan; Hunt, Peter; Karim, Roksana; Kern, David M.; Hodis, Howard N.; Deeks, Steven G.

In: Journal of Infectious Diseases, Vol. 203, No. 4, 15.02.2011, p. 452-463.

Research output: Contribution to journalArticle

Kaplan, RC, Sinclair, E, Landay, AL, Lurain, N, Sharrett, AR, Gange, SJ, Xue, X, Hunt, P, Karim, R, Kern, DM, Hodis, HN & Deeks, SG 2011, 'T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women', Journal of Infectious Diseases, vol. 203, no. 4, pp. 452-463. https://doi.org/10.1093/infdis/jiq071
Kaplan, Robert C. ; Sinclair, Elizabeth ; Landay, Alan L. ; Lurain, Nell ; Sharrett, A. Richey ; Gange, Stephen J ; Xue, Xiaonan ; Hunt, Peter ; Karim, Roksana ; Kern, David M. ; Hodis, Howard N. ; Deeks, Steven G. / T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women. In: Journal of Infectious Diseases. 2011 ; Vol. 203, No. 4. pp. 452-463.
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abstract = "Background. Individuals infected with human immunodeficiency virus (HIV) have increased risk of cardiovascular events. It is unknown whether T cell activation and senescence, 2 immunologic sequelae of HIV infection, are associated with vascular disease among HIV-infected adults. Methods. T cell phenotyping and carotid ultrasound were assessed among 115 HIV-infected women and 43 age- and race/ethnicity-matched HIV-uninfected controls participating in the Women's Interagency HIV Study. Multivariate analyses were used to assess the association of T cell activation (CD38+HLA-DR+) and senescence (CD28-CD57+) with subclinical carotid artery disease. Results. Compared with HIV-uninfected women, frequencies of CD4 +CD38+HLA-DR+, CD8+CD38 +HLA-DR +, and CD8+CD28-CD57 + T cells were higher among HIV-infected women, including those who achieved viral suppression while receiving antiretroviral treatment. Among HIV-infected women, adjusted for age, antiretroviral medications, and viral load, higher frequencies of activated CD4+ and CD8+ T cells and immunosenescent CD8+ T cells were associated with increased prevalence of carotid artery lesions (prevalence ratiolesions associated with activated CD4+ T cells, 1.6 per SD [95{\%} confidence interval {CI}, 1.1-2.2]; P = .02; prevalence ratiolesions associated with activated CD8+ T cells, 2.0 per SD [95{\%} CI, 1.2-3.3]; P <.01; prevalence ratiolesions associated with senescent CD8 + T cells, 1.9 per SD [95{\%} CI, 1.1-3.1]; P = .01). Conclusions. HIV-associated T cell changes are associated with subclinical carotid artery abnormalities, which may be observed even among those patients achieving viral suppression with effective antiretroviral therapy.",
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T1 - T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women

AU - Kaplan, Robert C.

AU - Sinclair, Elizabeth

AU - Landay, Alan L.

AU - Lurain, Nell

AU - Sharrett, A. Richey

AU - Gange, Stephen J

AU - Xue, Xiaonan

AU - Hunt, Peter

AU - Karim, Roksana

AU - Kern, David M.

AU - Hodis, Howard N.

AU - Deeks, Steven G.

PY - 2011/2/15

Y1 - 2011/2/15

N2 - Background. Individuals infected with human immunodeficiency virus (HIV) have increased risk of cardiovascular events. It is unknown whether T cell activation and senescence, 2 immunologic sequelae of HIV infection, are associated with vascular disease among HIV-infected adults. Methods. T cell phenotyping and carotid ultrasound were assessed among 115 HIV-infected women and 43 age- and race/ethnicity-matched HIV-uninfected controls participating in the Women's Interagency HIV Study. Multivariate analyses were used to assess the association of T cell activation (CD38+HLA-DR+) and senescence (CD28-CD57+) with subclinical carotid artery disease. Results. Compared with HIV-uninfected women, frequencies of CD4 +CD38+HLA-DR+, CD8+CD38 +HLA-DR +, and CD8+CD28-CD57 + T cells were higher among HIV-infected women, including those who achieved viral suppression while receiving antiretroviral treatment. Among HIV-infected women, adjusted for age, antiretroviral medications, and viral load, higher frequencies of activated CD4+ and CD8+ T cells and immunosenescent CD8+ T cells were associated with increased prevalence of carotid artery lesions (prevalence ratiolesions associated with activated CD4+ T cells, 1.6 per SD [95% confidence interval {CI}, 1.1-2.2]; P = .02; prevalence ratiolesions associated with activated CD8+ T cells, 2.0 per SD [95% CI, 1.2-3.3]; P <.01; prevalence ratiolesions associated with senescent CD8 + T cells, 1.9 per SD [95% CI, 1.1-3.1]; P = .01). Conclusions. HIV-associated T cell changes are associated with subclinical carotid artery abnormalities, which may be observed even among those patients achieving viral suppression with effective antiretroviral therapy.

AB - Background. Individuals infected with human immunodeficiency virus (HIV) have increased risk of cardiovascular events. It is unknown whether T cell activation and senescence, 2 immunologic sequelae of HIV infection, are associated with vascular disease among HIV-infected adults. Methods. T cell phenotyping and carotid ultrasound were assessed among 115 HIV-infected women and 43 age- and race/ethnicity-matched HIV-uninfected controls participating in the Women's Interagency HIV Study. Multivariate analyses were used to assess the association of T cell activation (CD38+HLA-DR+) and senescence (CD28-CD57+) with subclinical carotid artery disease. Results. Compared with HIV-uninfected women, frequencies of CD4 +CD38+HLA-DR+, CD8+CD38 +HLA-DR +, and CD8+CD28-CD57 + T cells were higher among HIV-infected women, including those who achieved viral suppression while receiving antiretroviral treatment. Among HIV-infected women, adjusted for age, antiretroviral medications, and viral load, higher frequencies of activated CD4+ and CD8+ T cells and immunosenescent CD8+ T cells were associated with increased prevalence of carotid artery lesions (prevalence ratiolesions associated with activated CD4+ T cells, 1.6 per SD [95% confidence interval {CI}, 1.1-2.2]; P = .02; prevalence ratiolesions associated with activated CD8+ T cells, 2.0 per SD [95% CI, 1.2-3.3]; P <.01; prevalence ratiolesions associated with senescent CD8 + T cells, 1.9 per SD [95% CI, 1.1-3.1]; P = .01). Conclusions. HIV-associated T cell changes are associated with subclinical carotid artery abnormalities, which may be observed even among those patients achieving viral suppression with effective antiretroviral therapy.

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