Systolic–diastolic hypertension versus isolated systolic hypertension and incident heart failure in older adults: Insights from the Cardiovascular Health Study

Apostolos Tsimploulis, Helen M. Sheriff, Phillip H. Lam, Daniel J. Dooley, Markus S. Anker, Vasilios Papademetriou, Ross D. Fletcher, Charles Faselis, Gregg C. Fonarow, Prakash Deedwania, Michel White, Miroslava Valentova, Marc R. Blackman, Maciej Banach, Charity J. Morgan, Kannayiram Alagiakrishnan, Richard M. Allman, Wilbert S. Aronow, Stefan D. Anker, Ali Ahmed

Research output: Contribution to journalArticle

Abstract

Background Isolated systolic hypertension (ISH) is common in older adults and is a risk factor for incident heart failure (HF). We examined the association of systolic–diastolic hypertension (SDH) with incident HF and other outcomes in older adults. Methods In the Cardiovascular Health Study (CHS), 5776 community-dwelling adults ≥ 65 years had data on baseline systolic and diastolic blood pressure (SBP and DBP). We excluded those with DBP < 60 mmHg (n = 821), DBP ≥ 90 and SBP < 140 mmHg (n = 28), normal BP, taking anti-hypertensive drugs (n = 1138), normal BP, not taking anti-hypertensive drugs, history of hypertension (n = 193), and baseline HF (n = 101). Of the remaining 3495, 1838 had ISH (SBP ≥ 140 and DBP < 90 mmHg) and 240 had SDH (SBP ≥ 140 and DBP ≥ 90 mmHg). The main outcome was centrally-adjudicated incident HF over 13 years of follow-up. Results Participants had a mean (± SD) age of 73 (± 6) years, 57% were women, and 16% African American. Incident HF occurred in 25%, 22% and 11% of participants with ISH, SDH and no hypertension, respectively. Compared to no hypertension, multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for incident HF associated with ISH and SDH were 1.86 (1.51–2.30) and 1.73 (1.23–2.42), respectively. Cardiovascular mortality occurred in 22%, 24% and 9% of those with ISH, SDH and no hypertension, respectively with respective multivariable-adjusted HRs (95% CIs) of 1.88 (1.49–2.37) and 2.30 (1.64–3.24). Conclusion Among older adults with hypertension, both SDH and ISH have similar associations with incident HF and cardiovascular mortality.

Original languageEnglish (US)
Pages (from-to)11-16
Number of pages6
JournalInternational Journal of Cardiology
Volume235
DOIs
StatePublished - May 15 2017
Externally publishedYes

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Heart Failure
Hypertension
Health
Antihypertensive Agents
Blood Pressure
Independent Living
Mortality
African Americans
Confidence Intervals

Keywords

  • Incident heart failure
  • Isolated diastolic hypertension
  • Mortality
  • Systolic–diastolic hypertension

ASJC Scopus subject areas

  • Medicine(all)
  • Cardiology and Cardiovascular Medicine

Cite this

Systolic–diastolic hypertension versus isolated systolic hypertension and incident heart failure in older adults : Insights from the Cardiovascular Health Study. / Tsimploulis, Apostolos; Sheriff, Helen M.; Lam, Phillip H.; Dooley, Daniel J.; Anker, Markus S.; Papademetriou, Vasilios; Fletcher, Ross D.; Faselis, Charles; Fonarow, Gregg C.; Deedwania, Prakash; White, Michel; Valentova, Miroslava; Blackman, Marc R.; Banach, Maciej; Morgan, Charity J.; Alagiakrishnan, Kannayiram; Allman, Richard M.; Aronow, Wilbert S.; Anker, Stefan D.; Ahmed, Ali.

In: International Journal of Cardiology, Vol. 235, 15.05.2017, p. 11-16.

Research output: Contribution to journalArticle

Tsimploulis, A, Sheriff, HM, Lam, PH, Dooley, DJ, Anker, MS, Papademetriou, V, Fletcher, RD, Faselis, C, Fonarow, GC, Deedwania, P, White, M, Valentova, M, Blackman, MR, Banach, M, Morgan, CJ, Alagiakrishnan, K, Allman, RM, Aronow, WS, Anker, SD & Ahmed, A 2017, 'Systolic–diastolic hypertension versus isolated systolic hypertension and incident heart failure in older adults: Insights from the Cardiovascular Health Study', International Journal of Cardiology, vol. 235, pp. 11-16. https://doi.org/10.1016/j.ijcard.2017.02.139
Tsimploulis, Apostolos ; Sheriff, Helen M. ; Lam, Phillip H. ; Dooley, Daniel J. ; Anker, Markus S. ; Papademetriou, Vasilios ; Fletcher, Ross D. ; Faselis, Charles ; Fonarow, Gregg C. ; Deedwania, Prakash ; White, Michel ; Valentova, Miroslava ; Blackman, Marc R. ; Banach, Maciej ; Morgan, Charity J. ; Alagiakrishnan, Kannayiram ; Allman, Richard M. ; Aronow, Wilbert S. ; Anker, Stefan D. ; Ahmed, Ali. / Systolic–diastolic hypertension versus isolated systolic hypertension and incident heart failure in older adults : Insights from the Cardiovascular Health Study. In: International Journal of Cardiology. 2017 ; Vol. 235. pp. 11-16.
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title = "Systolic–diastolic hypertension versus isolated systolic hypertension and incident heart failure in older adults: Insights from the Cardiovascular Health Study",
abstract = "Background Isolated systolic hypertension (ISH) is common in older adults and is a risk factor for incident heart failure (HF). We examined the association of systolic–diastolic hypertension (SDH) with incident HF and other outcomes in older adults. Methods In the Cardiovascular Health Study (CHS), 5776 community-dwelling adults ≥ 65 years had data on baseline systolic and diastolic blood pressure (SBP and DBP). We excluded those with DBP < 60 mmHg (n = 821), DBP ≥ 90 and SBP < 140 mmHg (n = 28), normal BP, taking anti-hypertensive drugs (n = 1138), normal BP, not taking anti-hypertensive drugs, history of hypertension (n = 193), and baseline HF (n = 101). Of the remaining 3495, 1838 had ISH (SBP ≥ 140 and DBP < 90 mmHg) and 240 had SDH (SBP ≥ 140 and DBP ≥ 90 mmHg). The main outcome was centrally-adjudicated incident HF over 13 years of follow-up. Results Participants had a mean (± SD) age of 73 (± 6) years, 57{\%} were women, and 16{\%} African American. Incident HF occurred in 25{\%}, 22{\%} and 11{\%} of participants with ISH, SDH and no hypertension, respectively. Compared to no hypertension, multivariable-adjusted hazard ratios (HR) and 95{\%} confidence intervals (CI) for incident HF associated with ISH and SDH were 1.86 (1.51–2.30) and 1.73 (1.23–2.42), respectively. Cardiovascular mortality occurred in 22{\%}, 24{\%} and 9{\%} of those with ISH, SDH and no hypertension, respectively with respective multivariable-adjusted HRs (95{\%} CIs) of 1.88 (1.49–2.37) and 2.30 (1.64–3.24). Conclusion Among older adults with hypertension, both SDH and ISH have similar associations with incident HF and cardiovascular mortality.",
keywords = "Incident heart failure, Isolated diastolic hypertension, Mortality, Systolic–diastolic hypertension",
author = "Apostolos Tsimploulis and Sheriff, {Helen M.} and Lam, {Phillip H.} and Dooley, {Daniel J.} and Anker, {Markus S.} and Vasilios Papademetriou and Fletcher, {Ross D.} and Charles Faselis and Fonarow, {Gregg C.} and Prakash Deedwania and Michel White and Miroslava Valentova and Blackman, {Marc R.} and Maciej Banach and Morgan, {Charity J.} and Kannayiram Alagiakrishnan and Allman, {Richard M.} and Aronow, {Wilbert S.} and Anker, {Stefan D.} and Ali Ahmed",
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TY - JOUR

T1 - Systolic–diastolic hypertension versus isolated systolic hypertension and incident heart failure in older adults

T2 - Insights from the Cardiovascular Health Study

AU - Tsimploulis, Apostolos

AU - Sheriff, Helen M.

AU - Lam, Phillip H.

AU - Dooley, Daniel J.

AU - Anker, Markus S.

AU - Papademetriou, Vasilios

AU - Fletcher, Ross D.

AU - Faselis, Charles

AU - Fonarow, Gregg C.

AU - Deedwania, Prakash

AU - White, Michel

AU - Valentova, Miroslava

AU - Blackman, Marc R.

AU - Banach, Maciej

AU - Morgan, Charity J.

AU - Alagiakrishnan, Kannayiram

AU - Allman, Richard M.

AU - Aronow, Wilbert S.

AU - Anker, Stefan D.

AU - Ahmed, Ali

PY - 2017/5/15

Y1 - 2017/5/15

N2 - Background Isolated systolic hypertension (ISH) is common in older adults and is a risk factor for incident heart failure (HF). We examined the association of systolic–diastolic hypertension (SDH) with incident HF and other outcomes in older adults. Methods In the Cardiovascular Health Study (CHS), 5776 community-dwelling adults ≥ 65 years had data on baseline systolic and diastolic blood pressure (SBP and DBP). We excluded those with DBP < 60 mmHg (n = 821), DBP ≥ 90 and SBP < 140 mmHg (n = 28), normal BP, taking anti-hypertensive drugs (n = 1138), normal BP, not taking anti-hypertensive drugs, history of hypertension (n = 193), and baseline HF (n = 101). Of the remaining 3495, 1838 had ISH (SBP ≥ 140 and DBP < 90 mmHg) and 240 had SDH (SBP ≥ 140 and DBP ≥ 90 mmHg). The main outcome was centrally-adjudicated incident HF over 13 years of follow-up. Results Participants had a mean (± SD) age of 73 (± 6) years, 57% were women, and 16% African American. Incident HF occurred in 25%, 22% and 11% of participants with ISH, SDH and no hypertension, respectively. Compared to no hypertension, multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for incident HF associated with ISH and SDH were 1.86 (1.51–2.30) and 1.73 (1.23–2.42), respectively. Cardiovascular mortality occurred in 22%, 24% and 9% of those with ISH, SDH and no hypertension, respectively with respective multivariable-adjusted HRs (95% CIs) of 1.88 (1.49–2.37) and 2.30 (1.64–3.24). Conclusion Among older adults with hypertension, both SDH and ISH have similar associations with incident HF and cardiovascular mortality.

AB - Background Isolated systolic hypertension (ISH) is common in older adults and is a risk factor for incident heart failure (HF). We examined the association of systolic–diastolic hypertension (SDH) with incident HF and other outcomes in older adults. Methods In the Cardiovascular Health Study (CHS), 5776 community-dwelling adults ≥ 65 years had data on baseline systolic and diastolic blood pressure (SBP and DBP). We excluded those with DBP < 60 mmHg (n = 821), DBP ≥ 90 and SBP < 140 mmHg (n = 28), normal BP, taking anti-hypertensive drugs (n = 1138), normal BP, not taking anti-hypertensive drugs, history of hypertension (n = 193), and baseline HF (n = 101). Of the remaining 3495, 1838 had ISH (SBP ≥ 140 and DBP < 90 mmHg) and 240 had SDH (SBP ≥ 140 and DBP ≥ 90 mmHg). The main outcome was centrally-adjudicated incident HF over 13 years of follow-up. Results Participants had a mean (± SD) age of 73 (± 6) years, 57% were women, and 16% African American. Incident HF occurred in 25%, 22% and 11% of participants with ISH, SDH and no hypertension, respectively. Compared to no hypertension, multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for incident HF associated with ISH and SDH were 1.86 (1.51–2.30) and 1.73 (1.23–2.42), respectively. Cardiovascular mortality occurred in 22%, 24% and 9% of those with ISH, SDH and no hypertension, respectively with respective multivariable-adjusted HRs (95% CIs) of 1.88 (1.49–2.37) and 2.30 (1.64–3.24). Conclusion Among older adults with hypertension, both SDH and ISH have similar associations with incident HF and cardiovascular mortality.

KW - Incident heart failure

KW - Isolated diastolic hypertension

KW - Mortality

KW - Systolic–diastolic hypertension

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