Systolic time intervals in hypothyroidism: End organ function as a reflection of clinical status

G. D. Plotnick, D. L. Vassar, A. F. Parisi, B. P. Hamilton, N. H. Carliner, M. L. Fisher

Research output: Contribution to journalArticlepeer-review

Abstract

Systolic time intervals (STI) were determined in 14 hypothyroid patients who did not have congestive heart failure or atrial fibrillation, and who were not taking cardiotropic drugs. Compared to normals there was a significant decrease in the left ventricular ejection time (LVET) and there were significant increases in the pre-ejection period (PEP) and the PEP/LVET ratio. The prolongation of the PEP primarily reflected lengthening of the isovolumic contraction time. Serial recordings during thyroxine therapy in seven patients showed consistent changes in STI toward normal values. These results in hypothyroid patients complement our earlier data in hyperthyroid patients; they indicate that STI's are a sensitive measure of the heart as an end organ over the entire range of thyroid hormonal activity.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalUnknown Journal
Volume277
Issue number3
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Medicine(all)

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