Systolic improvement and mechanical resynchronization does not require electrical synchrony in the dilated failing heart with left bundle-branch block

Christophe Leclercq, Owen Faris, Richard Tunin, Jennifer Johnson, Ritsuchi Kato, Frank Evans, Julio Spinelli, Henry R Halperin, Elliot McVeigh, David A Kass

Research output: Contribution to journalArticle

Abstract

Background - Biventricular (BiV) and left ventricular (LV) pacing similarly augment systolic function in left bundle-branch block (LBBB)-failing hearts despite different electrical activation. We tested whether electrical synchrony is required to achieve mechanical synchronization and functional benefit from pacing. Methods and Results - Epicardial mapping, tagged MRI, and hemodynamics were obtained in dogs with LBBB-failing hearts during right atrial, LV, and BiV stimulation. BiV and LV both significantly improved chamber hemodynamics (eg, 25% increase in dP/dtmax and aortic pulse pressure) compared with atrial pacing-LBBB, and this improvement correlated with mechanical resynchronization. Electrical dispersion, however, decreased 13% with BiV but increased 23% with LV pacing (P

Original languageEnglish (US)
Pages (from-to)1760-1763
Number of pages4
JournalCirculation
Volume106
Issue number14
DOIs
StatePublished - Oct 1 2002

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Bundle-Branch Block
Epicardial Mapping
Hemodynamics
Arterial Pressure
Dogs

Keywords

  • Bundle-branch block
  • Electrical stimulation
  • Heart failure
  • Pacing
  • Ventricles

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Systolic improvement and mechanical resynchronization does not require electrical synchrony in the dilated failing heart with left bundle-branch block. / Leclercq, Christophe; Faris, Owen; Tunin, Richard; Johnson, Jennifer; Kato, Ritsuchi; Evans, Frank; Spinelli, Julio; Halperin, Henry R; McVeigh, Elliot; Kass, David A.

In: Circulation, Vol. 106, No. 14, 01.10.2002, p. 1760-1763.

Research output: Contribution to journalArticle

Leclercq, Christophe ; Faris, Owen ; Tunin, Richard ; Johnson, Jennifer ; Kato, Ritsuchi ; Evans, Frank ; Spinelli, Julio ; Halperin, Henry R ; McVeigh, Elliot ; Kass, David A. / Systolic improvement and mechanical resynchronization does not require electrical synchrony in the dilated failing heart with left bundle-branch block. In: Circulation. 2002 ; Vol. 106, No. 14. pp. 1760-1763.
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AU - Faris, Owen

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AU - Johnson, Jennifer

AU - Kato, Ritsuchi

AU - Evans, Frank

AU - Spinelli, Julio

AU - Halperin, Henry R

AU - McVeigh, Elliot

AU - Kass, David A

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N2 - Background - Biventricular (BiV) and left ventricular (LV) pacing similarly augment systolic function in left bundle-branch block (LBBB)-failing hearts despite different electrical activation. We tested whether electrical synchrony is required to achieve mechanical synchronization and functional benefit from pacing. Methods and Results - Epicardial mapping, tagged MRI, and hemodynamics were obtained in dogs with LBBB-failing hearts during right atrial, LV, and BiV stimulation. BiV and LV both significantly improved chamber hemodynamics (eg, 25% increase in dP/dtmax and aortic pulse pressure) compared with atrial pacing-LBBB, and this improvement correlated with mechanical resynchronization. Electrical dispersion, however, decreased 13% with BiV but increased 23% with LV pacing (P

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