Systolic blood pressure within an intermediate range may reduce memory loss in an elderly hypertensive cohort

Ned Sacktor, Sarah Gray, Claudia Kawas, Jeffrey Herbst, Paul Costa, Jerome Fleg

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of this study was to determine if maintenance of systolic blood pressure (BP) within a high range or low range among treated hypertensive patients increases the risk of memory decline. Biennial neuropsychological evaluations were performed on 158 hypertensive subjects. Decline/year was measured on the Cued Selective Reminding test (total free recall and delayed recall) in three systolic BP groups (low - i.e., mean systolic BP during the follow-up period < 135 mmHg; intermediate - i.e., 135 mmHg ≤ mean systolic BP ≤ 150 mmHg; high - i.e., mean systolic BP > 150 mmHg). In total free recall, the three systolic BP groups had significantly different declines per year (P = .02), with patients in the high subgroup showing the greatest decline. In delayed recall, the three systolic BP groups also showed significantly different declines per year (P = .04), with patients in the low subgroup having the greatest decline. Chronically elevated systolic BP > 150 mmHg is associated with accelerated memory decline compared to older treated hypertensive patients with systolic BP in an intermediate range. Chronically maintained systolic BP within a low normal range < 135 mmHg in older treated hypertensive subjects may be associated with accelerated memory decline, specifically in a test of delayed memory recall, compared to patients with systolic BP in an intermediate range. Optimal regulation of systolic BP may be a potential modifiable risk factor to prevent or minimize memory loss in older hypertensive patients.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Geriatric Psychiatry and Neurology
Volume12
Issue number1
DOIs
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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