Systems pharmacogenomics in yeast

Patrick Cahan, Sharon Marsh, Howard L. McLeod

Research output: Contribution to journalArticle

Abstract

Despite intense study, the mechanistic and therapeutic differences in cellular responses to DNA-damaging agents are not fully understood. In order to expand knowledge of DNA damage, the authors of this study assayed the effects of 12 anticancer agents on the complete pool of approximately 4700 homozygous deletion strains of Saccharomyces cerevisiae. The screens identified genes in well-characterized DNA, in addition to genes whose role in DNA-damage-response pathways had not previously been established.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalPharmacogenomics
Volume7
Issue number2
DOIs
StatePublished - Mar 2006
Externally publishedYes

Fingerprint

Pharmacogenetics
DNA Damage
Yeasts
DNA
Antineoplastic Agents
Genes
Saccharomyces cerevisiae
Therapeutics

Keywords

  • Chemotheraphy
  • Pharmacogenomics
  • Resistance
  • Systems biology

ASJC Scopus subject areas

  • Pharmacology
  • Genetics(clinical)

Cite this

Systems pharmacogenomics in yeast. / Cahan, Patrick; Marsh, Sharon; McLeod, Howard L.

In: Pharmacogenomics, Vol. 7, No. 2, 03.2006, p. 255-259.

Research output: Contribution to journalArticle

Cahan, Patrick ; Marsh, Sharon ; McLeod, Howard L. / Systems pharmacogenomics in yeast. In: Pharmacogenomics. 2006 ; Vol. 7, No. 2. pp. 255-259.
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