Systems biology of oxygen homeostasis

Debangshu Samanta, Nanduri R. Prabhakar, Gregg L. Semenza

Research output: Contribution to journalReview articlepeer-review

Abstract

Metazoan species maintain oxygen homeostasis through the activity of hypoxia-inducible factors, which are transcriptional activators that regulate the expression of hundreds of genes to match O2 supply and demand. Here, we review the involvement of hypoxia-inducible factors in the molecular physiology and pathophysiology of cellular O2 sensing, O2 delivery, O2 utilization, and systemic O2 sensing. WIREs Syst Biol Med 2017, 9:e1382. doi: 10.1002/wsbm.1382. For further resources related to this article, please visit the WIREs website.

Original languageEnglish (US)
Article numbere1382
JournalWiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume9
Issue number4
DOIs
StatePublished - Jul 1 2017

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

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