Systems biology: Interlinked fast and slow positive feedback loops drive reliable cell decisions

Onn Brandman, James E. Ferrell, Rong Li, Tobias Meyer

Research output: Contribution to journalArticlepeer-review

Abstract

Positive feedback is a ubiquitous signal transduction motif that allows systems to convert graded inputs into decisive, all-or-none outputs. Here we investigate why the positive feedback switches that regulate polarization of budding yeast, calcium signaling, Xenopus oocyte maturation, and various other processes use multiple interlinked loops rather than single positive feedback loops. Mathematical simulations revealed that linking fast and slow positive feedback loops creates a "dual-time" switch that is both rapidly inducible and resistant to noise in the upstream signaling system.

Original languageEnglish (US)
Pages (from-to)496-498
Number of pages3
JournalScience
Volume310
Issue number5747
DOIs
StatePublished - Oct 21 2005

ASJC Scopus subject areas

  • General

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