Systems Biology and Systems Medicine

Nathan D. Price, Lucas B. Edelman, Inyoul Lee, Hyuntae Yoo, Daehee Hwang, George Carlson, David J. Galas, James R. Heath, Leroy Hood

Research output: Chapter in Book/Report/Conference proceedingChapter


A systems approach to medicine argues that disease arises from disease-perturbed biological networks and the dynamically changing, altered patterns of gene expression controlled by these perturbed networks give rise to the disease manifestations. This chapter presents a systems view of biology and disease, and recent advances in state-of-the-art in vitro and in vivo diagnostics technologies. As these technologies mature, they will move towards a future of predictive, personalized, preventive, and participatory medicine. Two primary domains of biological information lend themselves readily to systems-level analysis: the static, digital information of the genome, and the dynamic information arising from environmental interactions with the subcellular, cellular, and tissue levels of organization. Digital genome information encodes two types of biological networks-protein interactions and gene regulatory networks. Protein networks transmit biological information for development, physiology, and metabolism. Other RNAs interacting with one another receive information from signal-transduction networks, integrate and modulate it, and convey the processed information to networks of genes or molecular machines that execute developmental and physiological functions. © 2010

Original languageEnglish (US)
Title of host publicationEssentials of Genomic and Personalized Medicine
PublisherElsevier Inc.
Number of pages11
ISBN (Print)9780123749345
StatePublished - 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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