Systems analysis of regulatory processes underlying eukaryotic gradient perception

J. Krishnan, Pablo A. Iglesias

Research output: Contribution to journalArticlepeer-review

Abstract

This paper analyzes regulatory processes involved in the biological process of directed cell locomotion-known as chemotaxis. We focus on the nature of regulation involved in a subprocess of chemotaxis called gradient perception. We examine two different models from a dynamics/control perspective to gain insight into the working mechanisms of these models. One model is a minimal model which reconciles gradient perception to the property of adaptation. The second model is a biochemical model of a lipid network and its regulation by enzymes. In both cases, we focus on the extent of regulation of the modules/networks by inputs, and examine various limiting cases. Both the models and the resulting insights have broader applicability than the context in which they were developed.

Original languageEnglish (US)
Pages (from-to)126-138
Number of pages13
JournalIEEE Transactions on Automatic Control
Volume53
Issue numberSPECIAL ISSUE
DOIs
StatePublished - Dec 1 2008

Keywords

  • Chemotaxis
  • Dynamic regulation
  • Gradient perception
  • Systems biology

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Computer Science Applications
  • Electrical and Electronic Engineering

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