Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain Selectively Binds Long Double-stranded RNA and Is Required for RNA Transport by SID-1

Weiqiang Li, Kristin S. Koutmou, Daniel J. Leahy, Min Li

Research output: Contribution to journalArticle

Abstract

Background: SystemicRNAinterference deficiency-1 (SID-1) is a membrane protein required for cellular uptake ofRNAin C. elegans. Results: SID-1 extracellular domain selectively binds long dsRNA. Conclusion: Binding affinity between SID-1 ECD and dsRNA is related to RNA transport efficiency by SID-1. Significance: This defines SID-1 ECD as a functional domain for dsRNA recognition.

Original languageEnglish (US)
Pages (from-to)18904-18913
Number of pages10
JournalJournal of Biological Chemistry
Volume290
Issue number31
DOIs
StatePublished - Jul 31 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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