Systemic Lupus Erythematosus and Pregnancy

Aisha Lateef, Michelle Petri

Research output: Contribution to journalReview articlepeer-review


Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong female predilection. Pregnancy remains a commonly encountered but high-risk situation in this setting. Both maternal and fetal mortality and morbidity are still significantly increased despite improvements in outcomes. Maternal morbidity includes higher risk of disease flares, preeclampsia and other pregnancy-related complications. Fetal issues include higher rates of preterm birth, intrauterine growth restriction, and neonatal lupus syndromes. Treatment options during pregnancy are also limited and maternal benefit has to be weighed against fetal risk. A coordinated approach, with close monitoring by a multidisciplinary team, is essential for optimal outcomes.

Original languageEnglish (US)
Pages (from-to)215-226
Number of pages12
JournalRheumatic Disease Clinics of North America
Issue number2
StatePublished - May 1 2017


  • Antibodies
  • Fetal loss
  • Neonatal lupus syndromes
  • Preeclampsia
  • Pregnancy
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology


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