Systemic lupus erythematosus and pregnancy

Research output: Contribution to journalReview articlepeer-review


Although most women with systemic lupus erythematosus can achieve a successful pregnancy, fetal (fetal loss, preterm birth) and maternal (lupus flares, worsening renal function) morbidity remain major problems. Predictors of fetal loss and preterm birth have been identified and are reviewed. Modern management of lupus pregnancy includes identification of high-risk pregnancies with appropriate monitoring and treatment (when indicated) for anti-Ro and antiphospholipid antibodies, frequent assessment of and control of maternal lupus activity, adjustment of medications to avoid those associated with fetal teratogenicity, and the appropriate use of fetal assessment tests to guide intervention for the fetus at risk of intra-uterine death.

Original languageEnglish (US)
Pages (from-to)87-118
Number of pages32
JournalRheumatic Disease Clinics of North America
Issue number1
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Rheumatology

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