Systemic immunosuppressive agents were used by 85.7% and 78.5% of patients, respectively. Over time, patients with ANCA-positive vasculitis experienced 2.75-fold higher mortality than other patients with inflammatory eye disease. Ocular disease in patients with ANCA-positive vasculitis

Angela S. Watkins; John H. Kempen; Dongseok Choi; Teresa L. Liesegang; S. S. Pujari; Craig Newcomb; Robert B. Nussenblatt; James T. Rosenbaum; Jennifer E. Thorne; C. Stephen Foster; Douglas A. Jabs; Grace A. Levy-Clarke; Eric B. Suhler; Justine R. Smith

doi:10.1007/s12177-009-9044-4

Systemic immunosuppressive agents were used by 85.7% and 78.5% of patients, respectively. Over time, patients with ANCA-positive vasculitis experienced 2.75-fold higher mortality than other patients with inflammatory eye disease. Ocular disease in patients with ANCA-positive vasculitis

Angela S. Watkins, John H. Kempen, Dongseok Choi, Teresa L. Liesegang, S. S. Pujari, Craig Newcomb, Robert B. Nussenblatt, James T. Rosenbaum, Jennifer E. Thorne, C. Stephen Foster, Douglas A. Jabs, Grace A. Levy-Clarke, Eric B. Suhler, Justine R. Smith

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Abstract

Anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis-the term recently applied to Wegener's granulomatosis-is a rare multi-system inflammation characterized by necrotizing granulomas and vasculitis. We investigated the ocular manifestations of this disease in a group of patients drawn from five inflammatory eye disease clinics across the United States. Of 8,562 persons with ocular inflammation, 59 individuals were diagnosed with ANCA-positive vasculitis; 35 males and 21 females, aged 16 to 96 years, were included in this study. Ocular diagnoses were scleritis (75.0%), uveitis (17.9%), and other ocular inflammatory conditions (33.9%) including peripheral ulcer-ative keratitis and orbital pseudotumor. Mean duration of ocular disease was 4.6 years. Oral corticosteroids and other

Original language	English (US)
Pages (from-to)	12-19
Number of pages	8
Journal	Journal of Ocular Biology, Diseases, and Informatics
Volume	3
Issue number	1
DOIs	https://doi.org/10.1007/s12177-009-9044-4
State	Published - Mar 2010

Keywords

ANCA-positive vasculitis
Eye
Scleritis
Wegener's granulomatosis

ASJC Scopus subject areas

Ophthalmology
Genetics

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Watkins, A. S., Kempen, J. H., Choi, D., Liesegang, T. L., Pujari, S. S., Newcomb, C., Nussenblatt, R. B., Rosenbaum, J. T., Thorne, J. E., Foster, C. S., Jabs, D. A., Levy-Clarke, G. A., Suhler, E. B., & Smith, J. R. (2010). Systemic immunosuppressive agents were used by 85.7% and 78.5% of patients, respectively. Over time, patients with ANCA-positive vasculitis experienced 2.75-fold higher mortality than other patients with inflammatory eye disease. Ocular disease in patients with ANCA-positive vasculitis. Journal of Ocular Biology, Diseases, and Informatics, 3(1), 12-19. https://doi.org/10.1007/s12177-009-9044-4

Systemic immunosuppressive agents were used by 85.7% and 78.5% of patients, respectively. Over time, patients with ANCA-positive vasculitis experienced 2.75-fold higher mortality than other patients with inflammatory eye disease. Ocular disease in patients with ANCA-positive vasculitis. / Watkins, Angela S.; Kempen, John H.; Choi, Dongseok et al.
In: Journal of Ocular Biology, Diseases, and Informatics, Vol. 3, No. 1, 03.2010, p. 12-19.

Research output: Contribution to journal › Article › peer-review

Watkins, AS, Kempen, JH, Choi, D, Liesegang, TL, Pujari, SS, Newcomb, C, Nussenblatt, RB, Rosenbaum, JT, Thorne, JE, Foster, CS, Jabs, DA, Levy-Clarke, GA, Suhler, EB & Smith, JR 2010, 'Systemic immunosuppressive agents were used by 85.7% and 78.5% of patients, respectively. Over time, patients with ANCA-positive vasculitis experienced 2.75-fold higher mortality than other patients with inflammatory eye disease. Ocular disease in patients with ANCA-positive vasculitis', Journal of Ocular Biology, Diseases, and Informatics, vol. 3, no. 1, pp. 12-19. https://doi.org/10.1007/s12177-009-9044-4

Watkins AS, Kempen JH, Choi D, Liesegang TL, Pujari SS, Newcomb C et al. Systemic immunosuppressive agents were used by 85.7% and 78.5% of patients, respectively. Over time, patients with ANCA-positive vasculitis experienced 2.75-fold higher mortality than other patients with inflammatory eye disease. Ocular disease in patients with ANCA-positive vasculitis. Journal of Ocular Biology, Diseases, and Informatics. 2010 Mar;3(1):12-19. doi: 10.1007/s12177-009-9044-4

Watkins, Angela S. ; Kempen, John H. ; Choi, Dongseok et al. / Systemic immunosuppressive agents were used by 85.7% and 78.5% of patients, respectively. Over time, patients with ANCA-positive vasculitis experienced 2.75-fold higher mortality than other patients with inflammatory eye disease. Ocular disease in patients with ANCA-positive vasculitis. In: Journal of Ocular Biology, Diseases, and Informatics. 2010 ; Vol. 3, No. 1. pp. 12-19.

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abstract = "Anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis-the term recently applied to Wegener's granulomatosis-is a rare multi-system inflammation characterized by necrotizing granulomas and vasculitis. We investigated the ocular manifestations of this disease in a group of patients drawn from five inflammatory eye disease clinics across the United States. Of 8,562 persons with ocular inflammation, 59 individuals were diagnosed with ANCA-positive vasculitis; 35 males and 21 females, aged 16 to 96 years, were included in this study. Ocular diagnoses were scleritis (75.0%), uveitis (17.9%), and other ocular inflammatory conditions (33.9%) including peripheral ulcer-ative keratitis and orbital pseudotumor. Mean duration of ocular disease was 4.6 years. Oral corticosteroids and other",

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Systemic immunosuppressive agents were used by 85.7% and 78.5% of patients, respectively. Over time, patients with ANCA-positive vasculitis experienced 2.75-fold higher mortality than other patients with inflammatory eye disease. Ocular disease in patients with ANCA-positive vasculitis

Abstract

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