Systemic hematologic status following intraventricular recombinant tissue-type plasminogen activator for intraventricular hemorrhage the CLEAR IVH study group

Daniel B. Herrick, Wendy C. Ziai, Carol B. Thompson, Karen Lane, Nichol A. McBee, Daniel F. Hanley

Research output: Contribution to journalArticle


Background and Purpose: This is the first prospective evaluation of changes in systemic hematologic status following administration of intraventricular recombinant tissue-type plasminogen activator in patients with intraventricular hemorrhage (IVH). Methods: Laboratory data from subjects enrolled onto the Clot Lysis: Evaluating Accelerated Resolution of IVH (CLEAR IVH) Trials were analyzed. We analyzed pre-and post-recombinant tissue-type plasminogen activator dosing coagulation parameters. Longer-term changes in hematologic status were studied in subjects who received the study agent after blood clot in the third/fourth ventricles had resolved radiologically. Results: Plasma fibrinogen increased significantly in both treatment groups. Dosing did not have a significant impact on any systemic coagulation parameters in either treatment group. Conclusions: Intraventricular recombinant tissue-type plasminogen activator is unlikely to impact systemic coagulation or to compound the effects of systemic anticoagulation for deep venous thrombosis prophylaxis. Clinical Trial Registration: URL: Unique identifier: NCT00650858.

Original languageEnglish (US)
Pages (from-to)3631-3633
Number of pages3
Issue number12
StatePublished - Dec 1 2011



  • Coagulation
  • Intracerebral hemorrhage
  • Thrombolysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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