TY - JOUR
T1 - Systemic disorders associated with peripheral corneal ulceration
AU - Ladas, John G.
AU - Mondino, Bartly J.
PY - 2000
Y1 - 2000
N2 - Peripheral ulcerative keratitis may be associated with a variety of autoimmune diseases. In some diseases, corneal involvement occurs after the systemic disease has been present for many years, whereas in others, it may be the first manifestation. Regardless of the time of presentation, the development of corneal ulceration in the setting of systemic autoimmune disease may represent progression of a potentially life threatening disease. The relatively rare incidence of these diseases has limited publications over the past year to a few case series that have further characterized the natural history of the diseases associated with peripheral ulcerative keratitis. Current laboratory research has been directed at describing the antigenic targets within the cornea of the abnormal immune response in these patients and also the mechanism of keratolysis that results in ulceration. (C) 2000 Lippincott Williams and Wilkins, Inc.
AB - Peripheral ulcerative keratitis may be associated with a variety of autoimmune diseases. In some diseases, corneal involvement occurs after the systemic disease has been present for many years, whereas in others, it may be the first manifestation. Regardless of the time of presentation, the development of corneal ulceration in the setting of systemic autoimmune disease may represent progression of a potentially life threatening disease. The relatively rare incidence of these diseases has limited publications over the past year to a few case series that have further characterized the natural history of the diseases associated with peripheral ulcerative keratitis. Current laboratory research has been directed at describing the antigenic targets within the cornea of the abnormal immune response in these patients and also the mechanism of keratolysis that results in ulceration. (C) 2000 Lippincott Williams and Wilkins, Inc.
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U2 - 10.1097/00055735-200012000-00014
DO - 10.1097/00055735-200012000-00014
M3 - Article
C2 - 11141643
AN - SCOPUS:0033674646
SN - 1040-8738
VL - 11
SP - 468
EP - 471
JO - Current opinion in ophthalmology
JF - Current opinion in ophthalmology
IS - 6
ER -