Systemic cytokine levels do not predict CD4+ T-cell recovery after suppressive combination antiretroviral therapy in chronic human immunodeficiency virus Infection

the Women's Interagency HIV Study

Research output: Contribution to journalArticle

Abstract

Background. Subjects on suppressive combination antiretroviral therapy (cART) who do not achieve robust reconstitution of CD4+ T cells face higher risk of complications and death. We studied participants in theWomen's Interagency HIV Study with good (immunological responder [IR]) or poor (immunological nonresponder [INR]) CD4+ T-cell recovery after suppressive cART (n = 50 per group) to determine whether cytokine levels or low-level viral load correlated with INR status. Methods. A baseline sample prior to viral control and 2 subsequent samples 1 and 2 years after viral control were tested. Serum levels of 30 cytokines were measured at each time point, and low-level human immunodeficiency virus (HIV) viral load and anti-HIV antibody levels were measured 2 years after viral suppression. Results. There were minimal differences in cytokine levels between IR and INR subjects. At baseline, macrophage inflammatory protein-3ß levels were higher in IR subjects; after 1 year of suppressive cART, soluble vascular endothelial growth factor-R3 levels were higher in IR subjects; and after 2 years of suppressive cART, interferon gamma-induced protein 10 levels were higher in INR subjects. Very low-level HIV viral load and anti-HIV antibody levels did not differ between IR and INR subjects. Conclusion. These results imply that targeting residual viral replication might not be the optimum therapeutic approach for INR subjects.

Original languageEnglish (US)
Article numberofw025
JournalOpen Forum Infectious Diseases
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2016

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Virus Diseases
HIV
Cytokines
T-Lymphocytes
Viral Load
Macrophage Inflammatory Proteins
Therapeutics
Antibodies
Vascular Endothelial Growth Factor A
Interferon-gamma
Serum
Proteins

Keywords

  • CART
  • CD4 T cells
  • Chemokines
  • Cytokines
  • HIV

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

Cite this

Systemic cytokine levels do not predict CD4+ T-cell recovery after suppressive combination antiretroviral therapy in chronic human immunodeficiency virus Infection. / the Women's Interagency HIV Study.

In: Open Forum Infectious Diseases, Vol. 3, No. 1, ofw025, 01.01.2016.

Research output: Contribution to journalArticle

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abstract = "Background. Subjects on suppressive combination antiretroviral therapy (cART) who do not achieve robust reconstitution of CD4+ T cells face higher risk of complications and death. We studied participants in theWomen's Interagency HIV Study with good (immunological responder [IR]) or poor (immunological nonresponder [INR]) CD4+ T-cell recovery after suppressive cART (n = 50 per group) to determine whether cytokine levels or low-level viral load correlated with INR status. Methods. A baseline sample prior to viral control and 2 subsequent samples 1 and 2 years after viral control were tested. Serum levels of 30 cytokines were measured at each time point, and low-level human immunodeficiency virus (HIV) viral load and anti-HIV antibody levels were measured 2 years after viral suppression. Results. There were minimal differences in cytokine levels between IR and INR subjects. At baseline, macrophage inflammatory protein-3{\ss} levels were higher in IR subjects; after 1 year of suppressive cART, soluble vascular endothelial growth factor-R3 levels were higher in IR subjects; and after 2 years of suppressive cART, interferon gamma-induced protein 10 levels were higher in INR subjects. Very low-level HIV viral load and anti-HIV antibody levels did not differ between IR and INR subjects. Conclusion. These results imply that targeting residual viral replication might not be the optimum therapeutic approach for INR subjects.",
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AU - Norris, Philip J.

AU - Zhang, Jinbing

AU - Worlock, Andrew

AU - Nair, Sangeetha V.

AU - Anastos, Kathryn

AU - Minkoff, Howard L.

AU - Villacres, Maria C.

AU - Young, Mary

AU - Greenblatt, Ruth M.

AU - Desai, Seema

AU - Landay, Alan L.

AU - Gange, Stephen J

AU - Nugent, C. Thomas

AU - Golub, Elizabeth

AU - Keating, Sheila M.

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N2 - Background. Subjects on suppressive combination antiretroviral therapy (cART) who do not achieve robust reconstitution of CD4+ T cells face higher risk of complications and death. We studied participants in theWomen's Interagency HIV Study with good (immunological responder [IR]) or poor (immunological nonresponder [INR]) CD4+ T-cell recovery after suppressive cART (n = 50 per group) to determine whether cytokine levels or low-level viral load correlated with INR status. Methods. A baseline sample prior to viral control and 2 subsequent samples 1 and 2 years after viral control were tested. Serum levels of 30 cytokines were measured at each time point, and low-level human immunodeficiency virus (HIV) viral load and anti-HIV antibody levels were measured 2 years after viral suppression. Results. There were minimal differences in cytokine levels between IR and INR subjects. At baseline, macrophage inflammatory protein-3ß levels were higher in IR subjects; after 1 year of suppressive cART, soluble vascular endothelial growth factor-R3 levels were higher in IR subjects; and after 2 years of suppressive cART, interferon gamma-induced protein 10 levels were higher in INR subjects. Very low-level HIV viral load and anti-HIV antibody levels did not differ between IR and INR subjects. Conclusion. These results imply that targeting residual viral replication might not be the optimum therapeutic approach for INR subjects.

AB - Background. Subjects on suppressive combination antiretroviral therapy (cART) who do not achieve robust reconstitution of CD4+ T cells face higher risk of complications and death. We studied participants in theWomen's Interagency HIV Study with good (immunological responder [IR]) or poor (immunological nonresponder [INR]) CD4+ T-cell recovery after suppressive cART (n = 50 per group) to determine whether cytokine levels or low-level viral load correlated with INR status. Methods. A baseline sample prior to viral control and 2 subsequent samples 1 and 2 years after viral control were tested. Serum levels of 30 cytokines were measured at each time point, and low-level human immunodeficiency virus (HIV) viral load and anti-HIV antibody levels were measured 2 years after viral suppression. Results. There were minimal differences in cytokine levels between IR and INR subjects. At baseline, macrophage inflammatory protein-3ß levels were higher in IR subjects; after 1 year of suppressive cART, soluble vascular endothelial growth factor-R3 levels were higher in IR subjects; and after 2 years of suppressive cART, interferon gamma-induced protein 10 levels were higher in INR subjects. Very low-level HIV viral load and anti-HIV antibody levels did not differ between IR and INR subjects. Conclusion. These results imply that targeting residual viral replication might not be the optimum therapeutic approach for INR subjects.

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