Systemic complement activation in age-related macular degeneration

Hendrik P N Scholl, Peter Charbel Issa, Maja Walier, Stefanie Janzer, Beatrix Pollok-Kopp, Florian Börncke, Lars G. Fritsche, Ngaihang V. Chong, Rolf Fimmers, Thomas Wienker, Frank G. Holz, Bernhard H F Weber, Martin Oppermann

Research output: Contribution to journalArticle

Abstract

Dysregulation of the alternative pathway (AP) of complement cascade has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly. To further test the hypothesis that defective control of complement activation underlies AMD, parameters of complement activation in blood, plasm were determined together with disease-associated genetic markers in AMD patients. Plasma concentrations of activation products C3d, Ba, C3a, Ga, SC5b-9, substrate proteins C3, C4, factor B and regulators factor H and factor b were quantified in patients (n = 112) and controls (n = 67). Subjects were analyzed for single nucleotide polymorphisms in factor H (CFH), factor B-C2 (BF-C2) and complement C3 (C3) genes which were previously found to be associated witt AMD. All activation products, especially markers of chronic complement activation Ba and C3d (p

Original languageEnglish (US)
Article numbere2593
JournalPLoS One
Volume3
Issue number7
DOIs
StatePublished - Jul 2 2008
Externally publishedYes

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Complement Activation
Macular Degeneration
complement
Chemical activation
Complement Factor H
Complement C3d
Alternative Complement Pathway
Complement C3
Complement Factor B
Blindness
Genetic Markers
blindness
Single Nucleotide Polymorphism
Polymorphism
single nucleotide polymorphism
Blood
pathogenesis
Nucleotides
Genes
macular degeneration

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Scholl, H. P. N., Issa, P. C., Walier, M., Janzer, S., Pollok-Kopp, B., Börncke, F., ... Oppermann, M. (2008). Systemic complement activation in age-related macular degeneration. PLoS One, 3(7), [e2593]. https://doi.org/10.1371/journal.pone.0002593

Systemic complement activation in age-related macular degeneration. / Scholl, Hendrik P N; Issa, Peter Charbel; Walier, Maja; Janzer, Stefanie; Pollok-Kopp, Beatrix; Börncke, Florian; Fritsche, Lars G.; Chong, Ngaihang V.; Fimmers, Rolf; Wienker, Thomas; Holz, Frank G.; Weber, Bernhard H F; Oppermann, Martin.

In: PLoS One, Vol. 3, No. 7, e2593, 02.07.2008.

Research output: Contribution to journalArticle

Scholl, HPN, Issa, PC, Walier, M, Janzer, S, Pollok-Kopp, B, Börncke, F, Fritsche, LG, Chong, NV, Fimmers, R, Wienker, T, Holz, FG, Weber, BHF & Oppermann, M 2008, 'Systemic complement activation in age-related macular degeneration', PLoS One, vol. 3, no. 7, e2593. https://doi.org/10.1371/journal.pone.0002593
Scholl HPN, Issa PC, Walier M, Janzer S, Pollok-Kopp B, Börncke F et al. Systemic complement activation in age-related macular degeneration. PLoS One. 2008 Jul 2;3(7). e2593. https://doi.org/10.1371/journal.pone.0002593
Scholl, Hendrik P N ; Issa, Peter Charbel ; Walier, Maja ; Janzer, Stefanie ; Pollok-Kopp, Beatrix ; Börncke, Florian ; Fritsche, Lars G. ; Chong, Ngaihang V. ; Fimmers, Rolf ; Wienker, Thomas ; Holz, Frank G. ; Weber, Bernhard H F ; Oppermann, Martin. / Systemic complement activation in age-related macular degeneration. In: PLoS One. 2008 ; Vol. 3, No. 7.
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