Systemic and local antibody responses in eldery subjects given live or inactivated influenza A virus vaccines

D. C. Powers, S. D. Sears, B. R. Murphy, Bhagvanji Thumar, M. L. Clements

Research output: Contribution to journalArticle

Abstract

Intranasal live attenuated cold-adapted (ca) influenza A/Kawasaki/9/86 (H1N1) reassortant virus and parenteral inactivated influenza A/Taiwan/1/86 (H1N1) virus were given alone or in combination to 80 ambulatory elderly subjects. An enzyme-linked immunosorbent assay was used to measure hemagglutinin-specific (HA) antibodies in serum and nasal wash specimens collected before vaccination and 1 and 3 months later. Serum immunoglobulin G (IgG) and nasal wash IgA HA responses were elicited in 56 and 20%, respectively, of 25 inactivated-virus vaccinees and in 67 and 48%, respectively, of 27 recipients of both vaccines but in only 36 and 25%, respectively, of 28 vaccinees given live virus alone. Inactivated virus, administered alone or with live virus vaccine, induced higher titers of serum antibody than did the live virus alone. In contrast, nasal IgA HA antibody was elicited more often and in greater quantity by the vaccine combination than by either vaccine alone. Despite these differences, the peak titers of local antibody mounted by each group of vaccinees were similar. By 3 months postvaccination, serum IgG and nasal IgA HA antibody titers remained elevated above prevaccination levels in 50 and 17%, respectively, of the inactivated-virus vaccinees and in 46 and 23%, respectively, of recipients of both vaccines but in only 19 and 7%, respectively, of the live-virus vaccinees. The finding that live ca influenza A virus induced short-lived local and systemic antibodies, if confirmed, suggests that live virus vaccination may not be a suitable alternative or adjunct to inactivated virus vaccination for the elderly.

Original languageEnglish (US)
Pages (from-to)2666-2671
Number of pages6
JournalJournal of Clinical Microbiology
Volume27
Issue number12
StatePublished - 1989

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Influenza Vaccines
Influenza A virus
Antibody Formation
Viruses
Hemagglutinins
Nose
Antibodies
Vaccines
Immunoglobulin A
H1N1 Subtype Influenza A Virus
Vaccination
Serum
Human Influenza
Immunoglobulin G
Reassortant Viruses
Combined Vaccines
Taiwan
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Powers, D. C., Sears, S. D., Murphy, B. R., Thumar, B., & Clements, M. L. (1989). Systemic and local antibody responses in eldery subjects given live or inactivated influenza A virus vaccines. Journal of Clinical Microbiology, 27(12), 2666-2671.

Systemic and local antibody responses in eldery subjects given live or inactivated influenza A virus vaccines. / Powers, D. C.; Sears, S. D.; Murphy, B. R.; Thumar, Bhagvanji; Clements, M. L.

In: Journal of Clinical Microbiology, Vol. 27, No. 12, 1989, p. 2666-2671.

Research output: Contribution to journalArticle

Powers, DC, Sears, SD, Murphy, BR, Thumar, B & Clements, ML 1989, 'Systemic and local antibody responses in eldery subjects given live or inactivated influenza A virus vaccines', Journal of Clinical Microbiology, vol. 27, no. 12, pp. 2666-2671.
Powers, D. C. ; Sears, S. D. ; Murphy, B. R. ; Thumar, Bhagvanji ; Clements, M. L. / Systemic and local antibody responses in eldery subjects given live or inactivated influenza A virus vaccines. In: Journal of Clinical Microbiology. 1989 ; Vol. 27, No. 12. pp. 2666-2671.
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