Systemic and intraventricular naloxone administration: Effects on food and water intake

Mary A. Hynes; Michela Gallagher; Karen V. Yacos

doi:10.1016/S0163-1047(81)92385-2

Systemic and intraventricular naloxone administration: Effects on food and water intake

Mary A. Hynes, Michela Gallagher, Karen V. Yacos

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Previous research has demonstrated that systemic administration of the opiate antagonist naloxone suppresses consummatory behaviors in rodents. This study was conducted to compare the effects of systemic and intraventricular administration of naloxone on food and water intake in rats. Intraperitoneal injections of naloxone (0.5-5.0 mg/kg) significantly decreased both food and water intake following 24 hr of deprivation. However, no significant effects on either food or water intake were observed following administration of naloxone (0.5-50 μg) into the lateral ventricles. These results indicate that additional studies into the site(s) and mechanism(s) of naloxone's effects on consummatory behaviors are required.

Original language	English (US)
Pages (from-to)	334-342
Number of pages	9
Journal	Behavioral and Neural Biology
Volume	32
Issue number	3
DOIs	https://doi.org/10.1016/S0163-1047(81)92385-2
State	Published - Jul 1981
Externally published	Yes

ASJC Scopus subject areas

Physiology

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10.1016/S0163-1047(81)92385-2

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title = "Systemic and intraventricular naloxone administration: Effects on food and water intake",

abstract = "Previous research has demonstrated that systemic administration of the opiate antagonist naloxone suppresses consummatory behaviors in rodents. This study was conducted to compare the effects of systemic and intraventricular administration of naloxone on food and water intake in rats. Intraperitoneal injections of naloxone (0.5-5.0 mg/kg) significantly decreased both food and water intake following 24 hr of deprivation. However, no significant effects on either food or water intake were observed following administration of naloxone (0.5-50 μg) into the lateral ventricles. These results indicate that additional studies into the site(s) and mechanism(s) of naloxone's effects on consummatory behaviors are required.",

author = "Hynes, {Mary A.} and Michela Gallagher and Yacos, {Karen V.}",

note = "Funding Information: 1 Supported by USPHS Grant MH32292. 2 To whom requests for reprints should be sent at present address: Department of Psychology, Davie Hall 013A, University of North Carolina, Chapel Hill, N.C. 27514. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1981",

month = jul,

doi = "10.1016/S0163-1047(81)92385-2",

language = "English (US)",

volume = "32",

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journal = "Behavioral and Neural Biology",

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T1 - Systemic and intraventricular naloxone administration

T2 - Effects on food and water intake

AU - Hynes, Mary A.

AU - Gallagher, Michela

AU - Yacos, Karen V.

N1 - Funding Information: 1 Supported by USPHS Grant MH32292. 2 To whom requests for reprints should be sent at present address: Department of Psychology, Davie Hall 013A, University of North Carolina, Chapel Hill, N.C. 27514. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1981/7

Y1 - 1981/7

N2 - Previous research has demonstrated that systemic administration of the opiate antagonist naloxone suppresses consummatory behaviors in rodents. This study was conducted to compare the effects of systemic and intraventricular administration of naloxone on food and water intake in rats. Intraperitoneal injections of naloxone (0.5-5.0 mg/kg) significantly decreased both food and water intake following 24 hr of deprivation. However, no significant effects on either food or water intake were observed following administration of naloxone (0.5-50 μg) into the lateral ventricles. These results indicate that additional studies into the site(s) and mechanism(s) of naloxone's effects on consummatory behaviors are required.

AB - Previous research has demonstrated that systemic administration of the opiate antagonist naloxone suppresses consummatory behaviors in rodents. This study was conducted to compare the effects of systemic and intraventricular administration of naloxone on food and water intake in rats. Intraperitoneal injections of naloxone (0.5-5.0 mg/kg) significantly decreased both food and water intake following 24 hr of deprivation. However, no significant effects on either food or water intake were observed following administration of naloxone (0.5-50 μg) into the lateral ventricles. These results indicate that additional studies into the site(s) and mechanism(s) of naloxone's effects on consummatory behaviors are required.

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Systemic and intraventricular naloxone administration: Effects on food and water intake

Abstract

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