Systematic review of hypertriglyceridemia-induced acute pancreatitis: A more virulent etiology?

Rosalie A. Carr, Benjamin J. Rejowski, Gregory A. Cote, Henry A. Pitt, Nicholas J. Zyromski

Research output: Contribution to journalArticle

Abstract

Objective: We sought to define the severity and natural history of hypertriglyceridemia induced acute pancreatitis (HTG-AP), specifically whether HTG-AP causes more severe AP than that caused by other etiologies. Methods: Systematic review of the English literature. Results: Thirty-four studies (15 countries; 1972-2015) included 1340 HTG-AP patients (weighted mean prevalence of 9%). The median admission triglyceride concentration was 2622 mg/dl (range 1160-9769). Patients with HTG have a 14% weighted mean prevalence of AP. Plasmapheresis decreased circulating triglycerides, but did not conclusively affect AP mortality. Only 7 reports (n = 392 patients) compared severity of HTG-AP to that of AP from other etiologies. Of these, 2 studies found no difference in severity, while 5 suggested that HTG-AP patients may have increased severity compared to AP of other etiology. Conclusions: 1) hypertriglyceridemia is a relatively uncommon (9%) cause of acute pancreatitis; however, patients with hypertriglyceridemia have a high (14%) incidence of acute pancreatitis; 2) plasmapheresis may offer specific therapy unique to this patient population; and 3) data specifically comparing the severity of HTG-AP with AP caused by other etiologies are heterogeneous and scarce.

Original languageEnglish (US)
JournalPancreatology
DOIs
StateAccepted/In press - 2016
Externally publishedYes

Fingerprint

Hypertriglyceridemia
Pancreatitis
Plasmapheresis
Triglycerides
Mortality
Incidence
Population

Keywords

  • Acute pancreatitis
  • Etiology
  • Hypertriglyceridemia
  • Necrotizing pancreatitis
  • Plasmapheresis
  • Systematic review

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Hepatology

Cite this

Systematic review of hypertriglyceridemia-induced acute pancreatitis : A more virulent etiology? / Carr, Rosalie A.; Rejowski, Benjamin J.; Cote, Gregory A.; Pitt, Henry A.; Zyromski, Nicholas J.

In: Pancreatology, 2016.

Research output: Contribution to journalArticle

Carr, Rosalie A. ; Rejowski, Benjamin J. ; Cote, Gregory A. ; Pitt, Henry A. ; Zyromski, Nicholas J. / Systematic review of hypertriglyceridemia-induced acute pancreatitis : A more virulent etiology?. In: Pancreatology. 2016.
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