TY - JOUR
T1 - Synthetic steriod (R2323) as a once-a-week oral contraceptive
AU - David, S. S.
AU - Huggins, G. R.
AU - Garcia, C. R.
AU - Busacca, C.
PY - 1979
Y1 - 1979
N2 - Five milligrams of the steroid R2323 (13-β-ethyl-17 α-ethynyl-17hydroxygona-4,9,11-trien-3-one (R2323) were administered orally once weekly to 28 subjects for a total of 138 treatment cycles. No pregnancies occurred. The predominant side effects were irregular vaginal bleeding, headache, weight gain, and acne. Administration of the drug was stopped by the investigator in 4 patients (14%) because of the onset of headaches. Four patients discontinued the drug for other reasons. In 8 of 26 subjects (31%), endometrial biosy in the third treatment cycle showed secretory endometrium. This suggests a variable central suppression with the 5-mg dose schedule. Patients were enthusiastic about the once-weekly oral administration. This contraceptive may be useful in a select group of women.
AB - Five milligrams of the steroid R2323 (13-β-ethyl-17 α-ethynyl-17hydroxygona-4,9,11-trien-3-one (R2323) were administered orally once weekly to 28 subjects for a total of 138 treatment cycles. No pregnancies occurred. The predominant side effects were irregular vaginal bleeding, headache, weight gain, and acne. Administration of the drug was stopped by the investigator in 4 patients (14%) because of the onset of headaches. Four patients discontinued the drug for other reasons. In 8 of 26 subjects (31%), endometrial biosy in the third treatment cycle showed secretory endometrium. This suggests a variable central suppression with the 5-mg dose schedule. Patients were enthusiastic about the once-weekly oral administration. This contraceptive may be useful in a select group of women.
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U2 - 10.1016/s0015-0282(16)43874-4
DO - 10.1016/s0015-0282(16)43874-4
M3 - Article
C2 - 255131
AN - SCOPUS:0018333101
SN - 0015-0282
VL - 31
SP - 278
EP - 281
JO - Fertility and sterility
JF - Fertility and sterility
IS - 3
ER -