Synthetic Articulation of Miktoarm Polymers for Applications in Biology

Anjali Sharma, Rishi Sharma, Ahmed Abouelmagd, Ashok Kakkar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Asymmetric branched macromolecules, commonly referred to as miktoarm polymers, possess unique topological structures and physico-chemical properties, which make them promising candidates for applications in therapeutics and theranostics. The multiple polymeric arms of varied compositions in miktoarm stars present a platform with immense potential to tailor loading capacities of active pharmaceutical agents, and introduce multitasking units at the outer periphery or in the interior of self-assembled nanostructures. One of the key challenges in the past in the development of nanocarriers based on miktoarm polymers was their fabrication with a precise number of different polymeric segments, which required complex synthetic procedures and stringent purification protocols. With the advances in synthetic methodologies, a variety of miktoarm stars have been developed with demonstrated enhanced nanocarrier stability, high drug loading capability, controlled release profile, and stimulus responsiveness. This chapter describes the advances in the synthesis of miktoarm polymers, and the advantages of synthetically articulated precise branched structures in the design of intelligent nanoscale systems for biological applications, especially in drug delivery and multitasking.

Original languageEnglish (US)
Title of host publicationFluorinated Polymers, Volume 1
Subtitle of host publicationSynthesis, Properties, Processing and Simulation
EditorsBen Zhong Tang, Ashok Kakkar
PublisherRoyal Society of Chemistry
Pages150-180
Number of pages31
Edition25
DOIs
StatePublished - Jan 1 2017

Publication series

NameRSC Polymer Chemistry Series
Number25
Volume2017-January
ISSN (Print)2044-0790
ISSN (Electronic)2044-0804

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics

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  • Cite this

    Sharma, A., Sharma, R., Abouelmagd, A., & Kakkar, A. (2017). Synthetic Articulation of Miktoarm Polymers for Applications in Biology. In B. Z. Tang, & A. Kakkar (Eds.), Fluorinated Polymers, Volume 1: Synthesis, Properties, Processing and Simulation (25 ed., pp. 150-180). (RSC Polymer Chemistry Series; Vol. 2017-January, No. 25). Royal Society of Chemistry. https://doi.org/10.1039/9781788010429-00150