Synthesizing biomolecule-based boolean logic gates

Takafumi Miyamoto, Shiva Razavi, Robert Derose, Takanari Inoue

Research output: Contribution to journalReview articlepeer-review


One fascinating recent avenue of study in the field of synthetic biology is the creation of biomolecule-based computers. The main components of a computing device consist of an arithmetic logic unit, the control unit, memory, and the input and output devices. Boolean logic gates are at the core of the operational machinery of these parts, and hence to make biocomputers a reality, biomolecular logic gates become a necessity. Indeed, with the advent of more sophisticated biological tools, both nucleic acid- and protein-based logic systems have been generated. These devices function in the context of either test tubes or living cells and yield highly specific outputs given a set of inputs. In this review, we discuss various types of biomolecular logic gates that have been synthesized, with particular emphasis on recent developments that promise increased complexity of logic gate circuitry, improved computational speed, and potential clinical applications.

Original languageEnglish (US)
Pages (from-to)72-82
Number of pages11
JournalACS Synthetic Biology
Issue number2
StatePublished - Feb 15 2013


  • Boolean logic gate
  • biocomputers
  • biomolecular devices
  • chemically inducible dimerization
  • circuit design
  • synthetic biology

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

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