Synthesis, structure, and EPR characterization of deuterated derivatives of Finland trityl radical

Ilirian Dhimitruka, Olga Grigorieva, Jay L. Zweier, Valery V. Khramtsov

Research output: Contribution to journalArticle

Abstract

Substituted trityl radicals are important spin probes for functional electron paramagnetic resonance spectroscopy and imaging including oxygen and pH mapping in vivo. Here we report the synthetic procedure for large scale synthesis of deuterated Finland trityl radical with superior EPR spectral properties and higher sensitivity towards oxygen concentrations in solution. Additionally Finland trityl radicals substituted with linkers suitable for attaching peptide, or other synthetic precursors have been synthesized. The effect of deutero-substitution on EPR spectra of homologous derivatives has been evaluated. The compounds are potential candidates for targeted spin probes in EPR imaging.

Original languageEnglish (US)
Pages (from-to)3946-3949
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number13
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Deuterated trityl radicals
  • Electron paramagnetic resonance
  • EPR imaging
  • EPR oximetry
  • Trityl radicals

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

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