Synthesis, radiometal labeling and in vitro evaluation of a targeted PPIX derivative

Babak Behnam Azad, Choi Fong Cho, John D. Lewis, Leonard G. Luyt

Research output: Contribution to journalArticle

Abstract

In pursuit of a single molecule with potential applications for both in vitro fluorescence microscopy and in vivo PET imaging, novel targeted 69/71Ga/ 68Ga-protoporphyrin IX (PPIX) probes were developed. Optical analysis, fluorescence microscopy and radiolabeling with gallium-68 were performed to confirm potential applications. The use of a targeted-PPIX ring, in conjunction with 69/71Ga or 68Ga, eliminates the need for the attachment of multiple imaging tags, allowing for either in vitro fluorescent-based evaluation or in vivo nuclear-based imaging.

Original languageEnglish (US)
Pages (from-to)505-511
Number of pages7
JournalApplied Radiation and Isotopes
Volume70
Issue number3
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

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Keywords

  • Fluorescence microscopy
  • Gallium-68
  • Metal conjugates
  • Molecular imaging
  • PPIX
  • Radiolabeling

ASJC Scopus subject areas

  • Radiation

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