Synthesis, radiometal labeling and in vitro evaluation of a targeted PPIX derivative

Babak Behnam Azad, Choi Fong Cho, John D. Lewis, Leonard G. Luyt

Research output: Contribution to journalArticle

Abstract

In pursuit of a single molecule with potential applications for both in vitro fluorescence microscopy and in vivo PET imaging, novel targeted 69/71Ga/ 68Ga-protoporphyrin IX (PPIX) probes were developed. Optical analysis, fluorescence microscopy and radiolabeling with gallium-68 were performed to confirm potential applications. The use of a targeted-PPIX ring, in conjunction with 69/71Ga or 68Ga, eliminates the need for the attachment of multiple imaging tags, allowing for either in vitro fluorescent-based evaluation or in vivo nuclear-based imaging.

Original languageEnglish (US)
Pages (from-to)505-511
Number of pages7
JournalApplied Radiation and Isotopes
Volume70
Issue number3
DOIs
StatePublished - Mar 2012
Externally publishedYes

Fingerprint

marking
microscopy
fluorescence
evaluation
synthesis
gallium
attachment
probes
rings
molecules

Keywords

  • Fluorescence microscopy
  • Gallium-68
  • Metal conjugates
  • Molecular imaging
  • PPIX
  • Radiolabeling

ASJC Scopus subject areas

  • Radiation

Cite this

Synthesis, radiometal labeling and in vitro evaluation of a targeted PPIX derivative. / Behnam Azad, Babak; Cho, Choi Fong; Lewis, John D.; Luyt, Leonard G.

In: Applied Radiation and Isotopes, Vol. 70, No. 3, 03.2012, p. 505-511.

Research output: Contribution to journalArticle

Behnam Azad, Babak ; Cho, Choi Fong ; Lewis, John D. ; Luyt, Leonard G. / Synthesis, radiometal labeling and in vitro evaluation of a targeted PPIX derivative. In: Applied Radiation and Isotopes. 2012 ; Vol. 70, No. 3. pp. 505-511.
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