Synthesis of the Thiazolone Analogue of the Acetylcholinesterase Inhibitor, Huperzine A

Alan P. Kozikowski, Werner Tückmantel, Ashima Saxena, Bhupendra P. Doctor

Research output: Contribution to journalArticlepeer-review

Abstract

The preparation of an analogue 3a of the acetylcholinesterase inhibitor, huperzine A (1), is described in which the pyridinone moiety of the natural product is replaced with a thiazolone moiety. The synthesis started from cyclohexane‐1,4‐dione monoethylene ketal (7) by first annulating the thiazole ring using the Gewald protocol (→ 8; Scheme 1) and then constructing the bicyclo[3.3.1]nonane substructure using our previously described Michael addition/aldol condensation methodology (Scheme 3). The central problem was the protection of the thiazolone carbonyl group; only the 2‐unsubstituted thiazole survived the reaction conditions of the first half of the synthesis. Refunctionalization was later effected by lithiation and subsequent chlorination with hexachloroethane (30→31). Compound 3a was ineffective in the acetylcholinesterase inhibition assay in concentrations up to 14 μM.

Original languageEnglish (US)
Pages (from-to)1256-1266
Number of pages11
JournalHelvetica Chimica Acta
Volume77
Issue number5
DOIs
StatePublished - Aug 10 1994

ASJC Scopus subject areas

  • Catalysis
  • Biochemistry
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Fingerprint Dive into the research topics of 'Synthesis of the Thiazolone Analogue of the Acetylcholinesterase Inhibitor, Huperzine A'. Together they form a unique fingerprint.

Cite this