Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii

James McNulty, Kunal Keskar, Hilary A. Jenkins, Nick H. Werstiuk, Claudia Bordón, Robert H Yolken, Lorraine V Brando

Research output: Contribution to journalArticle

Abstract

A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route, enabling the assembly of a mini-library of structural analogues. The first single crystal X-ray structural determination on a member of this series is reported along with SAR studies identifying potent inhibitors of invasion and replication of the parasitic protozoan Toxoplasma gondii.

Original languageEnglish (US)
Pages (from-to)10015-10024
Number of pages10
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number39
DOIs
StatePublished - Aug 12 2015

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Antiparasitic Agents
metabolites
Toxoplasma
Metabolites
Biological Products
inhibitors
Libraries
assembly
routes
X-Rays
Single crystals
analogs
X rays
single crystals
synthesis
products
x rays
nostodione A

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this

Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii. / McNulty, James; Keskar, Kunal; Jenkins, Hilary A.; Werstiuk, Nick H.; Bordón, Claudia; Yolken, Robert H; Brando, Lorraine V.

In: Organic and Biomolecular Chemistry, Vol. 13, No. 39, 12.08.2015, p. 10015-10024.

Research output: Contribution to journalArticle

McNulty, James ; Keskar, Kunal ; Jenkins, Hilary A. ; Werstiuk, Nick H. ; Bordón, Claudia ; Yolken, Robert H ; Brando, Lorraine V. / Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii. In: Organic and Biomolecular Chemistry. 2015 ; Vol. 13, No. 39. pp. 10015-10024.
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