Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii

James McNulty; Kunal Keskar; Hilary A. Jenkins; Nick H. Werstiuk; Claudia Bordón; Robert Yolken; Lorraine Jones-Brando

doi:10.1039/c5ob01506e

Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii

James McNulty, Kunal Keskar, Hilary A. Jenkins, Nick H. Werstiuk, Claudia Bordón, Robert Yolken, Lorraine Jones-Brando

School of Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route, enabling the assembly of a mini-library of structural analogues. The first single crystal X-ray structural determination on a member of this series is reported along with SAR studies identifying potent inhibitors of invasion and replication of the parasitic protozoan Toxoplasma gondii.

Original language	English (US)
Pages (from-to)	10015-10024
Number of pages	10
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	39
DOIs	https://doi.org/10.1039/c5ob01506e
State	Published - Aug 12 2015

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route, enabling the assembly of a mini-library of structural analogues. The first single crystal X-ray structural determination on a member of this series is reported along with SAR studies identifying potent inhibitors of invasion and replication of the parasitic protozoan Toxoplasma gondii.",

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AU - McNulty, James

AU - Keskar, Kunal

AU - Jenkins, Hilary A.

AU - Werstiuk, Nick H.

AU - Bordón, Claudia

AU - Yolken, Robert

AU - Jones-Brando, Lorraine

PY - 2015/8/12

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AB - A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route, enabling the assembly of a mini-library of structural analogues. The first single crystal X-ray structural determination on a member of this series is reported along with SAR studies identifying potent inhibitors of invasion and replication of the parasitic protozoan Toxoplasma gondii.

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Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii

Abstract

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