Synthesis of the benzofuran analogue of ILV, a new protein kinase C (PKC) activator

Alan P. Kozikowski, Dawei Ma, Linh Du, Nancy E. Lewin, Peter M. Blumberg

Research output: Contribution to journalArticlepeer-review

Abstract

In order to probe the effect of small structural changes on the PKC activity of the natural product indolactam V (ILV), a synthesis of its benzofuran analogue was developed. This compound was found to be similar in its activity to ILV, exhibiting a Ki of 17.3 ± 3.7 nM in the displacement of [3H]PDBU from PKCα.

Original languageEnglish (US)
Pages (from-to)637-640
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number4
DOIs
StatePublished - Feb 24 1994

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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