Synthesis of the 6- and 7-hydroxylated cocaines and pseudococaines

A. P. Kozikowski; D. Simoni; S. Manfredini; M. Roberti; J. Stoelwinder

doi:10.1016/0040-4039(96)01123-9

Synthesis of the 6- and 7-hydroxylated cocaines and pseudococaines

A. P. Kozikowski, D. Simoni, S. Manfredini, M. Roberti, J. Stoelwinder

School of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

In efforts aimed at further exploration of our finding that functionalization of the two-carbon bridge of cocaine can lead to a weak antagonist of cocaine, we report a route of the 6- and 7-hydroxylated analogues by use of the Willstatter synthesis. The hydroxylated derivatives can in principle be used to gain access to a diverse library of 6- and 7-functionalized cocaine analogues.

Original language	English (US)
Pages (from-to)	5333-5336
Number of pages	4
Journal	Tetrahedron Letters
Volume	37
Issue number	30
DOIs	https://doi.org/10.1016/0040-4039(96)01123-9
State	Published - Jul 22 1996

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/0040-4039(96)01123-9

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abstract = "In efforts aimed at further exploration of our finding that functionalization of the two-carbon bridge of cocaine can lead to a weak antagonist of cocaine, we report a route of the 6- and 7-hydroxylated analogues by use of the Willstatter synthesis. The hydroxylated derivatives can in principle be used to gain access to a diverse library of 6- and 7-functionalized cocaine analogues.",

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AU - Kozikowski, A. P.

AU - Simoni, D.

AU - Manfredini, S.

AU - Roberti, M.

AU - Stoelwinder, J.

PY - 1996/7/22

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N2 - In efforts aimed at further exploration of our finding that functionalization of the two-carbon bridge of cocaine can lead to a weak antagonist of cocaine, we report a route of the 6- and 7-hydroxylated analogues by use of the Willstatter synthesis. The hydroxylated derivatives can in principle be used to gain access to a diverse library of 6- and 7-functionalized cocaine analogues.

AB - In efforts aimed at further exploration of our finding that functionalization of the two-carbon bridge of cocaine can lead to a weak antagonist of cocaine, we report a route of the 6- and 7-hydroxylated analogues by use of the Willstatter synthesis. The hydroxylated derivatives can in principle be used to gain access to a diverse library of 6- and 7-functionalized cocaine analogues.

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Synthesis of the 6- and 7-hydroxylated cocaines and pseudococaines

Abstract

ASJC Scopus subject areas

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