Synthesis of superparamagnetic iron oxide (Magnetite) nanoparticles and their future application as therapeutic agents

Asha B. Seshadri, Sudeep Debnath, Feroze B. Mohamed, Scott H. Faro, Joan Z. Delalic, Daniel R. Strongin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The goal of this research is to develop a "Biomolecular Sensor" with magnetic nanoparticles implanted in it to detect and destroy cancerous cells by thermal ablation. The "Biomolecular sensor" consists of superparamagnetic iron oxide nanoparticles with externally attached antibodies. The antibodies will function as targeting agents to a specific tumor site. Superparamagnetic nanoparticles will be subjected to AC magnetic field to generate heat, which is used to destroy cancerous cells. This paper presents the method to synthesize Iron Oxide (Magnetite) nanoparticles and to measure/record the temperature elevation seen when they are subjected to AC magnetic field. This procedure of destroying cancerous cells by elevating temperature inside the tumor tissue is referred as "Hyperthermia". This process represents minimal invasive alternative for elimination of cancer cells at appropriate sites and is less harmful and preferred to other therapies such as Laser ablation, Chemotherapy, Radiotherapy, etc. Hyperthermia prevents the unnecessary heating of healthy tissues since only the injected magnetic particles in the tumor region absorb the magnetic field. In this study Iron oxide nanoparticles-Magnetite synthesized via co-precipitation method was exposed to AC magnetic field to generate heat. Magnetite is an ideal candidate for hyperthermia cancer treatment as it is highly biocompatible, exhibits low levels of toxicity and shows high saturation magnetic moment.

Original languageEnglish (US)
Title of host publicationProceedings - 2007 International Symposium on Microelectronics, IMAPS 2007
Pages1138-1145
Number of pages8
StatePublished - Dec 1 2007
Event40th International Symposium on Microelectronics, IMAPS 2007 - San Jose, CA, United States
Duration: Nov 11 2007Nov 15 2007

Publication series

NameProceedings - 2007 International Symposium on Microelectronics, IMAPS 2007

Other

Other40th International Symposium on Microelectronics, IMAPS 2007
CountryUnited States
CitySan Jose, CA
Period11/11/0711/15/07

Keywords

  • Biomolecular sensor
  • Hyperthermia
  • Magnetic nanoparticles

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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    Seshadri, A. B., Debnath, S., Mohamed, F. B., Faro, S. H., Delalic, J. Z., & Strongin, D. R. (2007). Synthesis of superparamagnetic iron oxide (Magnetite) nanoparticles and their future application as therapeutic agents. In Proceedings - 2007 International Symposium on Microelectronics, IMAPS 2007 (pp. 1138-1145). (Proceedings - 2007 International Symposium on Microelectronics, IMAPS 2007).