Synthesis of superparamagnetic iron oxide (Magnetite) nanoparticles and their future application as therapeutic agents

Asha B. Seshadri, Sudeep Debnath, Feroze B. Mohamed, Scott Faro, Joan Z. Delalic, Daniel R. Strongin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The goal of this research is to develop a "Biomolecular Sensor" with magnetic nanoparticles implanted in it to detect and destroy cancerous cells by thermal ablation. The "Biomolecular sensor" consists of superparamagnetic iron oxide nanoparticles with externally attached antibodies. The antibodies will function as targeting agents to a specific tumor site. Superparamagnetic nanoparticles will be subjected to AC magnetic field to generate heat, which is used to destroy cancerous cells. This paper presents the method to synthesize Iron Oxide (Magnetite) nanoparticles and to measure/record the temperature elevation seen when they are subjected to AC magnetic field. This procedure of destroying cancerous cells by elevating temperature inside the tumor tissue is referred as "Hyperthermia". This process represents minimal invasive alternative for elimination of cancer cells at appropriate sites and is less harmful and preferred to other therapies such as Laser ablation, Chemotherapy, Radiotherapy, etc. Hyperthermia prevents the unnecessary heating of healthy tissues since only the injected magnetic particles in the tumor region absorb the magnetic field. In this study Iron oxide nanoparticles-Magnetite synthesized via co-precipitation method was exposed to AC magnetic field to generate heat. Magnetite is an ideal candidate for hyperthermia cancer treatment as it is highly biocompatible, exhibits low levels of toxicity and shows high saturation magnetic moment.

Original languageEnglish (US)
Title of host publicationProceedings - 2007 International Symposium on Microelectronics, IMAPS 2007
Pages1138-1145
Number of pages8
StatePublished - Dec 1 2007
Externally publishedYes
Event40th International Symposium on Microelectronics, IMAPS 2007 - San Jose, CA, United States
Duration: Nov 11 2007Nov 15 2007

Other

Other40th International Symposium on Microelectronics, IMAPS 2007
CountryUnited States
CitySan Jose, CA
Period11/11/0711/15/07

Fingerprint

Magnetite nanoparticles
Iron oxides
Magnetic fields
Tumors
Nanoparticles
Antibodies
Tissue
Oncology
Chemotherapy
Sensors
Radiotherapy
Magnetite
Laser ablation
Coprecipitation
Ablation
Magnetic moments
Toxicity
Cells
Heating
Temperature

Keywords

  • Biomolecular sensor
  • Hyperthermia
  • Magnetic nanoparticles

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Seshadri, A. B., Debnath, S., Mohamed, F. B., Faro, S., Delalic, J. Z., & Strongin, D. R. (2007). Synthesis of superparamagnetic iron oxide (Magnetite) nanoparticles and their future application as therapeutic agents. In Proceedings - 2007 International Symposium on Microelectronics, IMAPS 2007 (pp. 1138-1145)

Synthesis of superparamagnetic iron oxide (Magnetite) nanoparticles and their future application as therapeutic agents. / Seshadri, Asha B.; Debnath, Sudeep; Mohamed, Feroze B.; Faro, Scott; Delalic, Joan Z.; Strongin, Daniel R.

Proceedings - 2007 International Symposium on Microelectronics, IMAPS 2007. 2007. p. 1138-1145.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Seshadri, AB, Debnath, S, Mohamed, FB, Faro, S, Delalic, JZ & Strongin, DR 2007, Synthesis of superparamagnetic iron oxide (Magnetite) nanoparticles and their future application as therapeutic agents. in Proceedings - 2007 International Symposium on Microelectronics, IMAPS 2007. pp. 1138-1145, 40th International Symposium on Microelectronics, IMAPS 2007, San Jose, CA, United States, 11/11/07.
Seshadri AB, Debnath S, Mohamed FB, Faro S, Delalic JZ, Strongin DR. Synthesis of superparamagnetic iron oxide (Magnetite) nanoparticles and their future application as therapeutic agents. In Proceedings - 2007 International Symposium on Microelectronics, IMAPS 2007. 2007. p. 1138-1145
Seshadri, Asha B. ; Debnath, Sudeep ; Mohamed, Feroze B. ; Faro, Scott ; Delalic, Joan Z. ; Strongin, Daniel R. / Synthesis of superparamagnetic iron oxide (Magnetite) nanoparticles and their future application as therapeutic agents. Proceedings - 2007 International Symposium on Microelectronics, IMAPS 2007. 2007. pp. 1138-1145
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