Synthesis of sulfated β-1,6-linked oligosaccharide mimetics: A novel potent inhibitor of HIV replication

Yoshitomo Suhara; Mie Ichikawa; James E K Hildreth; Yoshitaka Ichikawa

doi:10.1016/0040-4039(96)00327-9

Synthesis of sulfated β-1,6-linked oligosaccharide mimetics: A novel potent inhibitor of HIV replication

Yoshitomo Suhara, Mie Ichikawa, James E K Hildreth, Yoshitaka Ichikawa

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

A novel sulfated β(1→6)-linked oligosaccharide mimetics has been synthesized and found to be a potent inhibitor of HIV replication, with an IC₅₀ of 1 μM.

Original language	English (US)
Pages (from-to)	2549-2552
Number of pages	4
Journal	Tetrahedron Letters
Volume	37
Issue number	15
DOIs	https://doi.org/10.1016/0040-4039(96)00327-9
State	Published - Apr 8 1996

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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title = "Synthesis of sulfated β-1,6-linked oligosaccharide mimetics: A novel potent inhibitor of HIV replication",

abstract = "A novel sulfated β(1→6)-linked oligosaccharide mimetics has been synthesized and found to be a potent inhibitor of HIV replication, with an IC50 of 1 μM.",

author = "Yoshitomo Suhara and Mie Ichikawa and Hildreth, {James E K} and Yoshitaka Ichikawa",

year = "1996",

month = apr,

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doi = "10.1016/0040-4039(96)00327-9",

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T1 - Synthesis of sulfated β-1,6-linked oligosaccharide mimetics

T2 - A novel potent inhibitor of HIV replication

AU - Suhara, Yoshitomo

AU - Ichikawa, Mie

AU - Hildreth, James E K

AU - Ichikawa, Yoshitaka

PY - 1996/4/8

Y1 - 1996/4/8

N2 - A novel sulfated β(1→6)-linked oligosaccharide mimetics has been synthesized and found to be a potent inhibitor of HIV replication, with an IC50 of 1 μM.

AB - A novel sulfated β(1→6)-linked oligosaccharide mimetics has been synthesized and found to be a potent inhibitor of HIV replication, with an IC50 of 1 μM.

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U2 - 10.1016/0040-4039(96)00327-9

DO - 10.1016/0040-4039(96)00327-9

M3 - Article

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 15

ER -

Synthesis of sulfated β-1,6-linked oligosaccharide mimetics: A novel potent inhibitor of HIV replication

Abstract

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