Synthesis of structural variants of Staphylococcus aureus lipoteichoic acid (LTA)

Ignacio Figueroa-Perez, Andreas Stadelmaier, Siegfried Morath, Thomas Hartung, Richard R. Schmidt

Research output: Contribution to journalArticlepeer-review

Abstract

Based on 1,2-O-isopropylidene-sn-glycerol, which is readily available from d-mannitol, five chiral building blocks for the construction of structural variants of Staphylococcus aureus LTA designed and synthesized. Ligation of these building blocks led readily to the target molecules 1 and 2. They demonstrated that the d-alanine residues at the glycerophosphate backbone are decisive for the activation of the immune system.

Original languageEnglish (US)
Pages (from-to)493-506
Number of pages14
JournalTetrahedron Asymmetry
Volume16
Issue number2
DOIs
StatePublished - Jan 24 2005
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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