Synthesis of Staphylococcus aureus lipoteichoic acid derivatives for determining the minimal structural requirements for cytokine induction

Ignacio Figueroa-Perez, Andreas Stadelmaier, Susanne Deininger, Sonja von Aulock, Thomas Hartung, Richard R. Schmidt

Research output: Contribution to journalArticlepeer-review

Abstract

For the investigation of the minimal structural requirements for cytokine induction, Staphylococcus aureus lipoteichoic acid derivatives with two, three, four, and five glycerophosphate backbone moieties, carrying each a d-alanyl residue, were needed. Based on two different glycerophosphate building blocks and 6b-O-phosphitylated gentiobiosyl diacylglycerol the desired target molecules (compounds 1-4) could be readily obtained and provided for biological studies.

Original languageEnglish (US)
Pages (from-to)2901-2911
Number of pages11
JournalCarbohydrate Research
Volume341
Issue number18
DOIs
StatePublished - Dec 29 2006
Externally publishedYes

Keywords

  • Bacteria
  • Gram-positive
  • Lipoteichoic acid
  • Modifications
  • Synthesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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