Synthesis of Staphylococcus aureus lipoteichoic acid derivatives for determining the minimal structural requirements for cytokine induction

Ignacio Figueroa-Perez; Andreas Stadelmaier; Susanne Deininger; Sonja von Aulock; Thomas Hartung; Richard R. Schmidt

doi:10.1016/j.carres.2006.10.003

Synthesis of Staphylococcus aureus lipoteichoic acid derivatives for determining the minimal structural requirements for cytokine induction

Ignacio Figueroa-Perez, Andreas Stadelmaier, Susanne Deininger, Sonja von Aulock, Thomas Hartung, Richard R. Schmidt

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

For the investigation of the minimal structural requirements for cytokine induction, Staphylococcus aureus lipoteichoic acid derivatives with two, three, four, and five glycerophosphate backbone moieties, carrying each a d-alanyl residue, were needed. Based on two different glycerophosphate building blocks and 6b-O-phosphitylated gentiobiosyl diacylglycerol the desired target molecules (compounds 1-4) could be readily obtained and provided for biological studies.

Original language	English (US)
Pages (from-to)	2901-2911
Number of pages	11
Journal	Carbohydrate Research
Volume	341
Issue number	18
DOIs	https://doi.org/10.1016/j.carres.2006.10.003
State	Published - Dec 29 2006
Externally published	Yes

Keywords

Bacteria
Gram-positive
Lipoteichoic acid
Modifications
Synthesis

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Organic Chemistry

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10.1016/j.carres.2006.10.003

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title = "Synthesis of Staphylococcus aureus lipoteichoic acid derivatives for determining the minimal structural requirements for cytokine induction",

abstract = "For the investigation of the minimal structural requirements for cytokine induction, Staphylococcus aureus lipoteichoic acid derivatives with two, three, four, and five glycerophosphate backbone moieties, carrying each a d-alanyl residue, were needed. Based on two different glycerophosphate building blocks and 6b-O-phosphitylated gentiobiosyl diacylglycerol the desired target molecules (compounds 1-4) could be readily obtained and provided for biological studies.",

keywords = "Bacteria, Gram-positive, Lipoteichoic acid, Modifications, Synthesis",

author = "Ignacio Figueroa-Perez and Andreas Stadelmaier and Susanne Deininger and Aulock, {Sonja von} and Thomas Hartung and Schmidt, {Richard R.}",

note = "Funding Information: This work was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie. ",

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T1 - Synthesis of Staphylococcus aureus lipoteichoic acid derivatives for determining the minimal structural requirements for cytokine induction

AU - Figueroa-Perez, Ignacio

AU - Stadelmaier, Andreas

AU - Deininger, Susanne

AU - Aulock, Sonja von

AU - Hartung, Thomas

AU - Schmidt, Richard R.

N1 - Funding Information: This work was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie.

PY - 2006/12/29

Y1 - 2006/12/29

N2 - For the investigation of the minimal structural requirements for cytokine induction, Staphylococcus aureus lipoteichoic acid derivatives with two, three, four, and five glycerophosphate backbone moieties, carrying each a d-alanyl residue, were needed. Based on two different glycerophosphate building blocks and 6b-O-phosphitylated gentiobiosyl diacylglycerol the desired target molecules (compounds 1-4) could be readily obtained and provided for biological studies.

AB - For the investigation of the minimal structural requirements for cytokine induction, Staphylococcus aureus lipoteichoic acid derivatives with two, three, four, and five glycerophosphate backbone moieties, carrying each a d-alanyl residue, were needed. Based on two different glycerophosphate building blocks and 6b-O-phosphitylated gentiobiosyl diacylglycerol the desired target molecules (compounds 1-4) could be readily obtained and provided for biological studies.

KW - Bacteria

KW - Gram-positive

KW - Lipoteichoic acid

KW - Modifications

KW - Synthesis

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Synthesis of Staphylococcus aureus lipoteichoic acid derivatives for determining the minimal structural requirements for cytokine induction

Abstract

Keywords

ASJC Scopus subject areas

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