Synthesis of Staphylococcus aureus lipoteichoic acid derivatives for determining the minimal structural requirements for cytokine induction

Ignacio Figueroa-Perez, Andreas Stadelmaier, Susanne Deininger, Sonja von Aulock, Thomas Hartung, Richard R. Schmidt

Research output: Contribution to journalArticle

Abstract

For the investigation of the minimal structural requirements for cytokine induction, Staphylococcus aureus lipoteichoic acid derivatives with two, three, four, and five glycerophosphate backbone moieties, carrying each a d-alanyl residue, were needed. Based on two different glycerophosphate building blocks and 6b-O-phosphitylated gentiobiosyl diacylglycerol the desired target molecules (compounds 1-4) could be readily obtained and provided for biological studies.

Original languageEnglish (US)
Pages (from-to)2901-2911
Number of pages11
JournalCarbohydrate Research
Volume341
Issue number18
DOIs
StatePublished - Dec 29 2006
Externally publishedYes

Keywords

  • Bacteria
  • Gram-positive
  • Lipoteichoic acid
  • Modifications
  • Synthesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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