Synthesis of radiotracers for studying muscarinic cholinergic receptors in the living human brain using positron emission tomography: [11C]dexetimide and [11C]levetimide

Robert F. Dannals, Bengt Långström, Hayden T. Ravert, Alan A. Wilson, Henry N. Wagner

Research output: Contribution to journalArticlepeer-review

Abstract

Dexetimide (Fig. 1a), a potent muscarinic cholinergic receptor antagonist, and levetimide (Fig. 1b), its pharmacologically inactive enantiomer, were labeled with 11C for non-invasive in vivo studies of muscarinic cholinergic receptors in the human brain using positron emission tomography. The syntheses were completed in approximately 32 min using [α-11C]benzyl iodide as the precursor. The synthesis, purification, characterization and determination of specific activity are presented and discussed.

Original languageEnglish (US)
Pages (from-to)291-295
Number of pages5
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Volume39
Issue number4
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Radiation
  • Engineering(all)

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