Synthesis of radioiodinated naltrindole analogues: Ligands for studies of delta opioid receptors

Chris M. Kinter; John R. Lever

doi:10.1016/0969-8051(94)00149-E

Synthesis of radioiodinated naltrindole analogues

Ligands for studies of delta opioid receptors

Chris M. Kinter, John R. Lever

School of Medicine

Research output: Contribution to journal › Article

Abstract

Analogues of naltrindole and N1′-methylnaltrindole having radioiodine in the 7′-position of the indole ring have been prepared for evaluation as delta opioid receptor ligands. The no-carrier-added radiosyntheses were conducted by Cu(I) assisted nucleophilic exchange of radioiodide for bromide under reducing conditions at 190 °C. A combination of HPLC and solid-phase extraction gave the ¹²⁵I- or ¹²³I-labeled products in satisfactory yields (47%) with high radiochemical purities (>98%) and high specific activities (¹²⁵I: 43-68 GBq/μmol, 1155-1833 mCi/μmol; ¹²³I: >92GBq/μmol, 2500mCi/μmol).

Original language	English (US)
Pages (from-to)	599-606
Number of pages	8
Journal	Nuclear Medicine and Biology
Volume	22
Issue number	5
DOIs	https://doi.org/10.1016/0969-8051(94)00149-E
State	Published - 1995

Fingerprint

naltrindole

delta Opioid Receptor

Solid Phase Extraction

Bromides

High Pressure Liquid Chromatography

Ligands

indole

ASJC Scopus subject areas

Cancer Research
Molecular Medicine
Radiology Nuclear Medicine and imaging

Cite this

Kinter, C. M., & Lever, J. R. (1995). Synthesis of radioiodinated naltrindole analogues: Ligands for studies of delta opioid receptors. Nuclear Medicine and Biology, 22(5), 599-606. https://doi.org/10.1016/0969-8051(94)00149-E

Synthesis of radioiodinated naltrindole analogues : Ligands for studies of delta opioid receptors. / Kinter, Chris M.; Lever, John R.

In: Nuclear Medicine and Biology, Vol. 22, No. 5, 1995, p. 599-606.

Research output: Contribution to journal › Article

Kinter, CM & Lever, JR 1995, 'Synthesis of radioiodinated naltrindole analogues: Ligands for studies of delta opioid receptors', Nuclear Medicine and Biology, vol. 22, no. 5, pp. 599-606. https://doi.org/10.1016/0969-8051(94)00149-E

Kinter CM, Lever JR. Synthesis of radioiodinated naltrindole analogues: Ligands for studies of delta opioid receptors. Nuclear Medicine and Biology. 1995;22(5):599-606. https://doi.org/10.1016/0969-8051(94)00149-E

Kinter, Chris M. ; Lever, John R. / Synthesis of radioiodinated naltrindole analogues : Ligands for studies of delta opioid receptors. In: Nuclear Medicine and Biology. 1995 ; Vol. 22, No. 5. pp. 599-606.

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10.1016/0969-8051(94)00149-E