Synthesis of radioiodinated naltrindole analogues: Ligands for studies of delta opioid receptors

Chris M. Kinter, John R. Lever

Research output: Contribution to journalArticle

Abstract

Analogues of naltrindole and N1′-methylnaltrindole having radioiodine in the 7′-position of the indole ring have been prepared for evaluation as delta opioid receptor ligands. The no-carrier-added radiosyntheses were conducted by Cu(I) assisted nucleophilic exchange of radioiodide for bromide under reducing conditions at 190 °C. A combination of HPLC and solid-phase extraction gave the 125I- or 123I-labeled products in satisfactory yields (47%) with high radiochemical purities (>98%) and high specific activities (125I: 43-68 GBq/μmol, 1155-1833 mCi/μmol; 123I: >92GBq/μmol, 2500mCi/μmol).

Original languageEnglish (US)
Pages (from-to)599-606
Number of pages8
JournalNuclear Medicine and Biology
Volume22
Issue number5
DOIs
StatePublished - Jul 1995

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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