Synthesis of (pyridin-2-yl)hydrazone rhenium(i) tricarbonyl complexes that exhibit ph-sensitive fluorescence

S. Hapuarachchige, B. K. Bryant, J. B. Arterburn

Research output: Contribution to journalArticlepeer-review

Abstract

There is great potential for novel diagnostic and therapeutic agents that combine multiple imaging modalities. The combination of optical and radionuclide imaging systems is particularly promising for the improved management of cancer. We describe a new heteroorganometallacyclic system containing the (2-pyridyl)hydrazono-Re(CO)3 that exhibits pH-sensitive photophysical properties. This optical reporter group was easily incorporated into a novel synthetic probe for targeting estrogen receptors in cancer. The efficient complexation conditions are expected to be compatible with 99mTc- radiolabeling to obtain dual function imaging probes.

Original languageEnglish (US)
Pages (from-to)254-263
Number of pages10
JournalChemistry of Heterocyclic Compounds
Volume50
Issue number2
DOIs
StatePublished - May 2014
Externally publishedYes

Keywords

  • Chelate
  • Estrogen
  • Fluorescence
  • Hydrazone
  • Tricarbonylrhenium

ASJC Scopus subject areas

  • Organic Chemistry

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