Abstract
Eight monosaccharide analogs of the potent antitumor OSW saponins (2-9) were synthesized. One analog, 2-O-acetyl-α-l-arabinopyranoside 3, showed antiproliferative activity against the Jurkat cells (IC50 = 0.078 μM) comparable to that of the disaccharide derivative (1).
Original language | English (US) |
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Pages (from-to) | 1003-1007 |
Number of pages | 5 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 17 |
Issue number | 4 |
DOIs | |
State | Published - Feb 15 2007 |
Keywords
- Antiproliferative activities
- Glycosides
- OSW saponins
- Synthesis
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry