Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities

Pingping Tang, Fatemah Mamdani, Xiaoyi Hu, Jun O. Liu, Biao Yu

Research output: Contribution to journalArticlepeer-review

Abstract

Eight monosaccharide analogs of the potent antitumor OSW saponins (2-9) were synthesized. One analog, 2-O-acetyl-α-l-arabinopyranoside 3, showed antiproliferative activity against the Jurkat cells (IC50 = 0.078 μM) comparable to that of the disaccharide derivative (1).

Original languageEnglish (US)
Pages (from-to)1003-1007
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number4
DOIs
StatePublished - Feb 15 2007

Keywords

  • Antiproliferative activities
  • Glycosides
  • OSW saponins
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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