Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities

Pingping Tang, Fatemah Mamdani, Xiaoyi Hu, Jun Liu, Biao Yu

Research output: Contribution to journalArticle

Abstract

Eight monosaccharide analogs of the potent antitumor OSW saponins (2-9) were synthesized. One analog, 2-O-acetyl-α-l-arabinopyranoside 3, showed antiproliferative activity against the Jurkat cells (IC50 = 0.078 μM) comparable to that of the disaccharide derivative (1).

Original languageEnglish (US)
Pages (from-to)1003-1007
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number4
DOIs
StatePublished - Feb 15 2007

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Jurkat Cells
Monosaccharides
Disaccharides
Saponins
Sugars
Inhibitory Concentration 50
Derivatives

Keywords

  • Antiproliferative activities
  • Glycosides
  • OSW saponins
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities. / Tang, Pingping; Mamdani, Fatemah; Hu, Xiaoyi; Liu, Jun; Yu, Biao.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 4, 15.02.2007, p. 1003-1007.

Research output: Contribution to journalArticle

Tang, Pingping ; Mamdani, Fatemah ; Hu, Xiaoyi ; Liu, Jun ; Yu, Biao. / Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities. In: Bioorganic and Medicinal Chemistry Letters. 2007 ; Vol. 17, No. 4. pp. 1003-1007.
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