Synthesis of N1-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors

Jayanta Kumar Mukhopadhyaya, Alan P. Kozikowski, Ewa Grajkowska, Sergey Pshenichkin, Jarda T. Wroblewski

Research output: Contribution to journalArticle

Abstract

The chemical synthesis of a series of N1-substituted derivatives of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid [(2R,4R)-APDC] as constrained analogues of γ-substituted glutamic acids is described. Appropriate substitution of the N1-position results in agonist, partial agonist, or antagonist activity at mGluR2, mGluR3, and/or mGluR6.

Original languageEnglish (US)
Pages (from-to)1919-1924
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number14
DOIs
StatePublished - Jul 23 2001
Externally publishedYes

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Glutamates
Metabotropic Glutamate Receptors
Substitution reactions
Derivatives
pyrrolidine-2,4-dicarboxylic acid
metabotropic glutamate receptor 3
4-aminopyrrolidine-2,4-dicarboxylic acid
metabotropic glutamate receptor 6
metabotropic glutamate receptor 2

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis of N1-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors. / Mukhopadhyaya, Jayanta Kumar; Kozikowski, Alan P.; Grajkowska, Ewa; Pshenichkin, Sergey; Wroblewski, Jarda T.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 14, 23.07.2001, p. 1919-1924.

Research output: Contribution to journalArticle

Mukhopadhyaya, Jayanta Kumar ; Kozikowski, Alan P. ; Grajkowska, Ewa ; Pshenichkin, Sergey ; Wroblewski, Jarda T. / Synthesis of N1-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors. In: Bioorganic and Medicinal Chemistry Letters. 2001 ; Vol. 11, No. 14. pp. 1919-1924.
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AU - Wroblewski, Jarda T.

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