Synthesis of N1-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors

Jayanta Kumar Mukhopadhyaya, Alan P. Kozikowski, Ewa Grajkowska, Sergey Pshenichkin, Jarda T. Wroblewski

Research output: Contribution to journalArticle

Abstract

The chemical synthesis of a series of N1-substituted derivatives of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid [(2R,4R)-APDC] as constrained analogues of γ-substituted glutamic acids is described. Appropriate substitution of the N1-position results in agonist, partial agonist, or antagonist activity at mGluR2, mGluR3, and/or mGluR6.

Original languageEnglish (US)
Pages (from-to)1919-1924
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number14
DOIs
StatePublished - Jul 23 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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