Abstract
The radiochemical synthesis of N‐[11C‐methyl]‐L‐DOPA was accomplished by N‐methylation of the methyl and ethyl esters of L‐N‐tert‐butyl‐oxycarbonyl‐[β‐(3,4‐dimethoxyphenyl)] alaninate with [11C]iodomethane using sodium hydride in tetrahydrofuran and deprotection of the N‐methyl intermediate with hydriodic acid. A catalytic influence of Kryptofix on the methylation reaction was observed. Using the ethyl ester precursor, the average specific activity at the end‐of‐synthesis was 972 mCi/μmole. The synthesis was completed in an average of 45 minutes following the end‐of‐bombardment.
Original language | English (US) |
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Pages (from-to) | 1029-1036 |
Number of pages | 8 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 31 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1992 |
Keywords
- N‐[C‐methyl]‐L‐DOPA
- carbon‐11
- dopamine
- positron emission tomography
- radiotracer
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry