Synthesis of N‐[11C]‐methyl‐L‐DOPA

Andrew Horti, Hayden T. Ravert, Robert F. Dannals, Henry N. Wagner

Research output: Contribution to journalArticlepeer-review


The radiochemical synthesis of N‐[11C‐methyl]‐L‐DOPA was accomplished by N‐methylation of the methyl and ethyl esters of L‐N‐tert‐butyl‐oxycarbonyl‐[β‐(3,4‐dimethoxyphenyl)] alaninate with [11C]iodomethane using sodium hydride in tetrahydrofuran and deprotection of the N‐methyl intermediate with hydriodic acid. A catalytic influence of Kryptofix on the methylation reaction was observed. Using the ethyl ester precursor, the average specific activity at the end‐of‐synthesis was 972 mCi/μmole. The synthesis was completed in an average of 45 minutes following the end‐of‐bombardment.

Original languageEnglish (US)
Pages (from-to)1029-1036
Number of pages8
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number12
StatePublished - Dec 1992


  • N‐[C‐methyl]‐L‐DOPA
  • carbon‐11
  • dopamine
  • positron emission tomography
  • radiotracer

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry


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