Synthesis of N-[11C]-methyl-L-DOPA

Andrew Horti, H. T. Ravert, Robert F Dannals, H. N. Wagner

Research output: Contribution to journalArticle

Abstract

The radiochemical synthesis of N-[11C-methyl]-L-DOPA was accomplished by N-methylation of the methyl and ethyl esters of L-N-tert-butyl-oxycarbonyl-[β-(3,4-dimethoxyphenyl)] alaninate with [11C]iodomethane using sodium hydride in tetrahydrofuran and deprotection of the N-methyl intermediate with hydriodic acid. A catalytic influence of Kryptofix on the methylation reaction was observed. Using the ethyl ester precursor, the average specific activity at the end-of-synthesis was 972 mCi/μmole. The synthesis was completed in an average of 45 minutes following the end-of-bombardment.

Original languageEnglish (US)
Pages (from-to)1029-1036
Number of pages8
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume31
Issue number12
DOIs
StatePublished - 1992

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Methylation
Esters
hydroiodic acid
sodium hydride
tetrahydrofuran
methyl iodide

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Clinical Biochemistry
  • Molecular Medicine
  • Pharmacology

Cite this

Synthesis of N-[11C]-methyl-L-DOPA. / Horti, Andrew; Ravert, H. T.; Dannals, Robert F; Wagner, H. N.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 31, No. 12, 1992, p. 1029-1036.

Research output: Contribution to journalArticle

Horti, Andrew ; Ravert, H. T. ; Dannals, Robert F ; Wagner, H. N. / Synthesis of N-[11C]-methyl-L-DOPA. In: Journal of Labelled Compounds and Radiopharmaceuticals. 1992 ; Vol. 31, No. 12. pp. 1029-1036.
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