Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B

V. Rajendran; Ashima Saxena; Bhupendra P. Doctor; Alan P. Kozikowski

doi:10.1016/S0960-894X(02)00204-4

Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B

V. Rajendran, Ashima Saxena, Bhupendra P. Doctor, Alan P. Kozikowski

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The synthesis and acetylcholinesterase inhibition activity of analogues of huperzine B are reported. These new racemic analogues show a better AChE inhibitory activity than the natural product huperzine B.

Original language	English (US)
Pages (from-to)	1521-1523
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	11
DOIs	https://doi.org/10.1016/S0960-894X(02)00204-4
State	Published - Jun 3 2002
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(02)00204-4

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title = "Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B",

abstract = "The synthesis and acetylcholinesterase inhibition activity of analogues of huperzine B are reported. These new racemic analogues show a better AChE inhibitory activity than the natural product huperzine B.",

author = "V. Rajendran and Ashima Saxena and Doctor, {Bhupendra P.} and Kozikowski, {Alan P.}",

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T1 - Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B

AU - Rajendran, V.

AU - Saxena, Ashima

AU - Doctor, Bhupendra P.

AU - Kozikowski, Alan P.

PY - 2002/6/3

Y1 - 2002/6/3

N2 - The synthesis and acetylcholinesterase inhibition activity of analogues of huperzine B are reported. These new racemic analogues show a better AChE inhibitory activity than the natural product huperzine B.

AB - The synthesis and acetylcholinesterase inhibition activity of analogues of huperzine B are reported. These new racemic analogues show a better AChE inhibitory activity than the natural product huperzine B.

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U2 - 10.1016/S0960-894X(02)00204-4

DO - 10.1016/S0960-894X(02)00204-4

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AN - SCOPUS:0037013437

SN - 0960-894X

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EP - 1523

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 11

ER -

Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B

Abstract

ASJC Scopus subject areas

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