Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B

V. Rajendran, Ashima Saxena, Bhupendra P. Doctor, Alan P. Kozikowski

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis and acetylcholinesterase inhibition activity of analogues of huperzine B are reported. These new racemic analogues show a better AChE inhibitory activity than the natural product huperzine B.

Original languageEnglish (US)
Pages (from-to)1521-1523
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number11
DOIs
StatePublished - Jun 3 2002

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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