Synthesis of m-methoxynaphthylamines as precursors for chromogenic substrates

David H. Rosenblatt, Marvin M. Nachlas, Arnold M. Seligman

Research output: Contribution to journalArticle

Abstract

Because of the expected greater rate of coupling as compared to naphthylamine, 3-methoxy-1-naphthylamine and 4-methoxy-2-naphthylamiue have been synthesized for use in the preparation of chromogenic substrates for the histochemical demonstration of amidases and peptidases. The chloroacetamides, trifluoroacetamides and L-leucyl-4-methoxy-2-naphthyl amide also were prepared. The last derivative is a superior reagent for the histochemical demonstration of leucine amino peptidase.

Original languageEnglish (US)
Pages (from-to)2463-2465
Number of pages3
JournalJournal of the American Chemical Society
Volume80
Issue number10
StatePublished - 1958

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Chromogenics
Chromogenic Compounds
Peptide Hydrolases
Demonstrations
1-Naphthylamine
Amidohydrolases
Substrates
Amides
Leucine
Derivatives
trifluoroacetamide
chloroacetamide

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Rosenblatt, D. H., Nachlas, M. M., & Seligman, A. M. (1958). Synthesis of m-methoxynaphthylamines as precursors for chromogenic substrates. Journal of the American Chemical Society, 80(10), 2463-2465.

Synthesis of m-methoxynaphthylamines as precursors for chromogenic substrates. / Rosenblatt, David H.; Nachlas, Marvin M.; Seligman, Arnold M.

In: Journal of the American Chemical Society, Vol. 80, No. 10, 1958, p. 2463-2465.

Research output: Contribution to journalArticle

Rosenblatt, DH, Nachlas, MM & Seligman, AM 1958, 'Synthesis of m-methoxynaphthylamines as precursors for chromogenic substrates', Journal of the American Chemical Society, vol. 80, no. 10, pp. 2463-2465.
Rosenblatt, David H. ; Nachlas, Marvin M. ; Seligman, Arnold M. / Synthesis of m-methoxynaphthylamines as precursors for chromogenic substrates. In: Journal of the American Chemical Society. 1958 ; Vol. 80, No. 10. pp. 2463-2465.
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