Synthesis of m-Methoxynaphthylamines as Precursors for Chromogenic Substrates

David H. Rosenblatt, Marvin M. Nachlas, Arnold M. Seligman

Research output: Contribution to journalArticlepeer-review

Abstract

Because of the expected greater rate of coupling as compared to naphthylamine, 3-methoxy-1-naphthylamine and 4-methoxy-2-naphthylamine have been synthesized for use in the preparation of chromogenic substrates for the histochemical demonstration of amidases and peptidases. The chloroacetamides, trifluoroacetamides and L-leucyl-4-methoxy-2-naphthyl amide also were prepared. The last derivative is a superior reagent for the histochemical demonstration of leucine amino peptidase.

Original languageEnglish (US)
Pages (from-to)2463-2465
Number of pages3
JournalJournal of the American Chemical Society
Volume80
Issue number10
DOIs
StatePublished - May 1 1958

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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